{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Specific Functions","Enriched Functions","Peripheral Neuropaty"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Specific Functions","index":0,"n_rows":336,"n_cols":5,"rows_kept":336,"merged":[[1,0,1,255]],"flags":["formulas_cached_only"]}
["© 2000-2013 Ingenuity Systems, Inc. All rights reserved."]
["Ingenuity Pathway Analysis (IPA version 17199142, Ingenuity Systems; http://www.ingenuity.com) was used to summarize the molecular and cellular functions that were most strongly associated with genes linked to inherited peripheral neuropathies. Corresponding p-values in the supplementary files were calculated using Fisher’s exact test and corrected for multiple testing using the Benjamini-Hochberg method. Note that the same gene can be present in various clusters."]
[]
["Category","Diseases or Functions Annotation","p-Value","Molecules","# Molecules"]
["Carbohydrate Metabolism","production of phosphatidylinositol 3,4-diphosphate","6.06E-04","NGF,NTRK1","2"]
["Carbohydrate Metabolism","metabolism of phosphatidylinositol","9.06E-03","FIG4,MTMR2,NGF,NTRK1","4"]
["Carbohydrate Metabolism","dephosphorylation of phosphoinositide","1.75E-02","FIG4,MTMR2","2"]
["Carbohydrate Metabolism","synthesis of phosphoinositide","1.99E-02","MTMR2,NGF,NTRK1","3"]
["Carbohydrate Metabolism","quantity of phosphoinositide","1.99E-02","FIG4,NGF,NTRK1","3"]
["Carbohydrate Metabolism","localization of doxorubicin","1.99E-02","ATP7A","1"]
["Carbohydrate Metabolism","mobilization of D-glucose","1.99E-02","GJB1","1"]
[]
["Cell-To-Cell Signaling and Interaction","synthesis of acetylcholine","9.22E-05","NGF,NTRK1,SLC5A7","3"]
["Cell-To-Cell Signaling and Interaction","contact growth inhibition of bone cancer cell lines","6.06E-04","NGF,NTRK1","2"]
["Cell-To-Cell Signaling and Interaction","synthesis of neurotransmitter","1.08E-03","ATP7A,NGF,NTRK1,SLC5A7","4"]
["Cell-To-Cell Signaling and Interaction","metabolism of neurotransmitter","2.51E-03","ATP7A,NGF,NTRK1,SLC5A7","4"]
["Cell-To-Cell Signaling and Interaction","excitation of sensory neurons","8.73E-03","NGF,SCN9A","2"]
["Cell-To-Cell Signaling and Interaction","synthesis of norepinephrine","1.37E-02","ATP7A,NGF","2"]
["Cell-To-Cell Signaling and Interaction","neurotransmission","1.62E-02","FGD4,KIF1B,MPZ,NGF,PMP22,PRX,SCN9A,SLC5A7","8"]
["Cell-To-Cell Signaling and Interaction","development of gap junctions","1.77E-02","GJB1,KIF1A,NGF,NTRK1,SLC5A7","5"]
["Cell-To-Cell Signaling and Interaction","activation of monocyte-derived dendritic cells","1.89E-02","HSPB8,SCN9A","2"]
["Cell-To-Cell Signaling and Interaction","action potential of neurons","1.99E-02","FGD4,PMP22,PRX,SCN9A","4"]
["Cell-To-Cell Signaling and Interaction","synaptic transmission of neuromuscular synapse","1.99E-02","KIF1B,SLC5A7","2"]
["Cell-To-Cell Signaling and Interaction","activation of intercellular channels","1.99E-02","TRPV4","1"]
["Cell-To-Cell Signaling and Interaction","area of gap junction plaques","1.99E-02","GJB1","1"]
["Cell-To-Cell Signaling and Interaction","communication of acinar gland cells","1.99E-02","GJB1","1"]
["Cell-To-Cell Signaling and Interaction","compound action potential of muscle","1.99E-02","MPZ","1"]
["Cell-To-Cell Signaling and Interaction","coupling of hepatoma cell lines","1.99E-02","GJB1","1"]
["Cell-To-Cell Signaling and Interaction","delay in conduction of nerves","1.99E-02","MPZ","1"]
["Cell-To-Cell Signaling and Interaction","density of excitatory synapses","1.99E-02","MTMR2","1"]
["Cell-To-Cell Signaling and Interaction","firing of Adelta fiber","1.99E-02","NTRK1","1"]
["Cell-To-Cell Signaling and Interaction","firing of C fiber","1.99E-02","NTRK1","1"]
["Cell-To-Cell Signaling and Interaction","firing of motor neurons","1.99E-02","NGF","1"]
["Cell-To-Cell Signaling and Interaction","hyperexcitation of sensory neurons","1.99E-02","SCN9A","1"]
["Cell-To-Cell Signaling and Interaction","response of neuromuscular junctions","1.99E-02","SLC5A7","1"]
["Cell-To-Cell Signaling and Interaction","electrical resistance of cells","2.88E-02","DNM2,PMP22","2"]
["Cell-To-Cell Signaling and Interaction","response of neurons","2.88E-02","HSPB1,NGF","2"]
["Cell-To-Cell Signaling and Interaction","synaptogenesis","2.90E-02","KIF1A,NGF,NTRK1,SLC5A7","4"]
["Cell-To-Cell Signaling and Interaction","release of acetylcholine","3.00E-02","NGF,SLC5A7","2"]
["Cell-To-Cell Signaling and Interaction","activation of sensory neurons","3.00E-02","NGF","1"]
[]
["Cell Cycle","contact growth inhibition of bone cancer cell lines","6.06E-04","NGF,NTRK1","2"]
["Cell Cycle","arrest in cell division","2.73E-03","NEFL,NGF","2"]
["Cell Cycle","cell cycle progression of neuroblastoma cell lines","4.11E-03","NGF,NTRK1","2"]
["Cell Cycle","arrest in cleavage of cells","6.90E-03","NEFL,NGF","2"]
["Cell Cycle","elongation of filaments","1.89E-02","INF2,SEPT9","2"]
["Cell Cycle","M phase of cervical cancer cell lines","1.99E-02","DCTN1,LMNA,SEPT9","3"]
["Cell Cycle","aneuploidization of breast cell lines","1.99E-02","SEPT9","1"]
["Cell Cycle","arrest in cell division of brain cancer cell lines","1.99E-02","NEFL","1"]
["Cell Cycle","arrest in cell division of neuroblastoma cell lines","1.99E-02","NEFL","1"]
["Cell Cycle","cytokinesis of endothelial cell lines","1.99E-02","SEPT9","1"]
["Cell Cycle","late cytokinesis of cervical cancer cell lines","1.99E-02","SEPT9","1"]
["Cell Cycle","polyploidy of bladder cancer cell lines","1.99E-02","NDRG1","1"]
["Cell Cycle","polyploidy of colon cancer cell lines","1.99E-02","NDRG1","1"]
["Cell Cycle","polyploidy of mammary cells","1.99E-02","NDRG1","1"]
["Cell Cycle","prometaphase of bone cancer cell lines","1.99E-02","DCTN1","1"]
["Cell Cycle","ploidy","2.79E-02","NDRG1,PDK3,SEPT9,WNK1","4"]
["Cell Cycle","ploidy of epithelial cell lines","3.00E-02","PDK3,WNK1","2"]
[]
["Cell Death and Survival","neuronal cell death","2.66E-05","AARS,AIFM1,ATP7A,DNAJB2,FAM134B,HSPB1,KIF1A,KIF1B,MFN2,NEFL,NGF,NTRK1,SOX10,SURF1,TRIM2,VAPB","16"]
["Cell Death and Survival","necrosis","2.08E-04","AARS,AIFM1,ATP7A,CCT5,DCTN1,DNAJB2,DNM2,DNMT1,DST,EGR2,FAM134B,HINT1,HK1,HSPB1,HSPB8,IFRD1,KIF1A,KIF1B,LMNA,MFN2,NDRG1,NEFL,NGF,NTRK1,PMP22,SOX10,SPTLC2,SURF1,TRIM2,TUBB3,VAPB,YARS","32"]
["Cell Death and Survival","apoptosis of neurons","1.55E-03","AARS,AIFM1,ATP7A,FAM134B,HSPB1,NEFL,NGF,NTRK1,SURF1,TRIM2","10"]
["Cell Death and Survival","cell death","2.02E-03","AARS,AIFM1,ATP7A,CCT5,DCTN1,DNAJB2,DNM2,DNMT1,DST,DYNC1H1,EGR2,FAM134B,GJB1,HINT1,HK1,HSPB1,HSPB8,IFRD1,KIF1A,KIF1B,LMNA,MFN2,MPZ,NDRG1,NEFL,NGF,NTRK1,PMP22,SOX10,SPTLC2,SURF1,TRIM2,TUBB3,VAPB,YARS","35"]
["Cell Death and Survival","cell viability of sympathetic neuron","2.87E-03","HSPB1,NGF,NTRK1","3"]
["Cell Death and Survival","apoptosis of ganglion cells","4.68E-03","FAM134B,HSPB1,NGF","3"]
["Cell Death and Survival","cell death of neuroblastoma cell lines","4.68E-03","AIFM1,CCT5,DCTN1,DST,NGF,NTRK1","6"]
["Cell Death and Survival","loss of cholinergic neurons","5.56E-03","NGF,NTRK1","2"]
["Cell Death and Survival","cell viability of pheochromocytoma cell lines","6.90E-03","HINT1,NGF,NTRK1","3"]
["Cell Death and Survival","cell death of tumor cell lines","6.90E-03","AIFM1,CCT5,DCTN1,DNM2,DST,EGR2,HINT1,HK1,HSPB1,HSPB8,IFRD1,LMNA,MFN2,NDRG1,NGF,NTRK1,SOX10,TUBB3,YARS","19"]
["Cell Death and Survival","apoptosis of superior cervical ganglion neurons","6.90E-03","HSPB1,NGF","2"]
["Cell Death and Survival","loss of trigeminal ganglion neurons","6.90E-03","NGF,NTRK1","2"]
["Cell Death and Survival","survival of cholinergic neurons","6.90E-03","NGF,NTRK1","2"]
["Cell Death and Survival","cell viability","7.76E-03","AIFM1,ATP7A,DNM2,DNMT1,DST,HINT1,HSPB1,KIF1A,KIF1B,LMNA,NDRG1,NEFL,NGF,NTRK1,SETX,SOX10,TUBB3","17"]
["Cell Death and Survival","cell death of central nervous system cells","9.06E-03","AIFM1,FAM134B,HSPB1,MFN2,NGF,NTRK1,VAPB","7"]
["Cell Death and Survival","cell death of brain","9.43E-03","AIFM1,DNAJB2,HSPB1,MFN2,NGF,NTRK1,VAPB","7"]
["Cell Death and Survival","delay in cell death of neurons","1.01E-02","AIFM1,NGF","2"]
["Cell Death and Survival","loss of dorsal root ganglion cells","1.01E-02","NGF,NTRK1","2"]
["Cell Death and Survival","loss of sympathetic neuron","1.01E-02","NGF,NTRK1","2"]
["Cell Death and Survival","degeneration of neurons","1.18E-02","AIFM1,DYNC1H1,KIF1A,MPZ,NGF","5"]
["Cell Death and Survival","cell viability of embryonic cells","1.19E-02","DNMT1,NDRG1,SOX10","3"]
["Cell Death and Survival","apoptosis of dorsal root ganglion cells","1.37E-02","FAM134B,NGF","2"]
["Cell Death and Survival","apoptosis of Schwann cells","1.58E-02","EGR2,NGF","2"]
["Cell Death and Survival","cell viability of fibroblast cell lines","1.66E-02","ATP7A,HSPB1,LMNA,NGF","4"]
["Cell Death and Survival","cell viability of neuroblastoma cell lines","1.75E-02","DST,HSPB1,NTRK1","3"]
["Cell Death and Survival","cell death of epithelial cells","1.89E-02","AIFM1,HK1,HSPB1,HSPB8,NDRG1,NGF,NTRK1,PMP22","8"]
["Cell Death and Survival","cell viability of tumor cell lines","1.91E-02","AIFM1,DNM2,DST,HINT1,HSPB1,KIF1A,NGF,NTRK1,SETX,SOX10,TUBB3","11"]
["Cell Death and Survival","cell death of brain cells","1.99E-02","AIFM1,HSPB1,MFN2,NGF,NTRK1,VAPB","6"]
["Cell Death and Survival","cell viability of connective tissue cells","1.99E-02","LMNA,NGF,NTRK1,SETX","4"]
["Cell Death and Survival","cell death of epithelial cell lines","1.99E-02","AIFM1,HK1,HSPB1,HSPB8,NTRK1,PMP22","6"]
["Cell Death and Survival","cell death of cardiomyocytes","1.99E-02","HK1,HSPB1,HSPB8,MFN2,SPTLC2","5"]
["Cell Death and Survival","apoptosis of neuroblastoma cells","1.99E-02","NGF,NTRK1","2"]
["Cell Death and Survival","apoptosis of cancer cells","1.99E-02","AIFM1,HSPB8,NDRG1,NGF,NTRK1","5"]
["Cell Death and Survival","fragmentation of heterochromatin DNA","1.99E-02","LMNA","1"]
["Cell Death and Survival","self-renewal of leukemia stem cells","1.99E-02","DNMT1","1"]
["Cell Death and Survival","apoptosis","2.36E-02","AARS,AIFM1,ATP7A,DCTN1,DNM2,DNMT1,EGR2,FAM134B,GJB1,HINT1,HK1,HSPB1,HSPB8,LMNA,MFN2,NDRG1,NEFL,NGF,NTRK1,PMP22,SOX10,SPTLC2,SURF1,TRIM2,YARS","25"]
["Cell Death and Survival","cell viability of neurons","2.38E-02","HSPB1,KIF1B,NEFL,NGF,NTRK1","5"]
["Cell Death and Survival","apoptosis of neuroglia","2.79E-02","EGR2,NGF,NTRK1","3"]
["Cell Death and Survival","cell viability of fibroblasts","2.90E-02","LMNA,NGF,SETX","3"]
["Cell Death and Survival","cell death of muscle cells","2.95E-02","HK1,HSPB1,HSPB8,LMNA,MFN2,SPTLC2","6"]
["Cell Death and Survival","cell death of cerebellar granule cell","3.00E-02","AIFM1,MFN2","2"]
["Cell Death and Survival","apoptosis of cholinergic neurons","3.00E-02","NGF","1"]
["Cell Death and Survival","apoptosis of otic vesicle","3.00E-02","NGF","1"]
[]
["Cell Morphology","abnormal morphology of Schwann cells","1.13E-06","EGR2,GJB1,MPZ,PMP22,PRX","5"]
["Cell Morphology","morphology of axons","1.06E-05","GAN,GJB1,LMNA,MPZ,NEFL,PMP22,SLC12A6","7"]
["Cell Morphology","abnormal morphology of myelin sheath","2.20E-05","FGD4,GAN,GJB1,MPZ,PMP22","5"]
["Cell Morphology","abnormal morphology of axons","1.21E-04","GAN,GJB1,LMNA,NEFL,PMP22,SLC12A6","6"]
["Cell Morphology","neuritogenesis of pheochromocytoma cell lines","1.55E-03","NGF,NTRK1,TRPV4","3"]
["Cell Morphology","initiation of outgrowth of neurites","1.55E-03","NGF,NTRK1","2"]
["Cell Morphology","morphology of endoplasmic reticulum","6.90E-03","ATL1,PMP22","2"]
["Cell Morphology","formation of cellular protrusions","1.01E-02","ATL1,ATP7A,DNM2,FGD4,HSPB1,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","12"]
["Cell Morphology","neuritogenesis","1.08E-02","ATL1,ATP7A,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","9"]
["Cell Morphology","neuritogenesis of neuroblastoma cell lines","1.37E-02","NGF,NTRK1","2"]
["Cell Morphology","elongation of filaments","1.89E-02","INF2,SEPT9","2"]
["Cell Morphology","axonogenesis","1.99E-02","ATL1,MPZ,NGF,NTRK1,PMP22","5"]
["Cell Morphology","myelination of axons","1.99E-02","MPZ,PMP22","2"]
["Cell Morphology","morphology of nucleus","1.99E-02","AIFM1,DNMT1,LMNA","3"]
["Cell Morphology","area of gap junction plaques","1.99E-02","GJB1","1"]
["Cell Morphology","coalignment of microfilaments","1.99E-02","DST","1"]
["Cell Morphology","coalignment of neurofilaments","1.99E-02","DST","1"]
["Cell Morphology","innervation of sympathetic nerve","1.99E-02","NGF","1"]
["Cell Morphology","morphology of tomacula","1.99E-02","PMP22","1"]
["Cell Morphology","projection of cholinergic fibers","1.99E-02","NTRK1","1"]
["Cell Morphology","re-innervation of skeletal muscle","1.99E-02","IFRD1","1"]
["Cell Morphology","sprouting of cholinergic fibers","1.99E-02","NGF","1"]
["Cell Morphology","formation of lamellipodia","2.13E-02","DNM2,FGD4,HSPB1,NGF","4"]
["Cell Morphology","morphology of mitochondria","2.57E-02","AIFM1,GDAP1,MFN2","3"]
["Cell Morphology","size of neurons","2.58E-02","NGF,NTRK1","2"]
["Cell Morphology","electrical resistance of cells","2.88E-02","DNM2,PMP22","2"]
[]
["Cell Signaling","osmosensory signaling pathway","1.99E-02","TRPV4","1"]
["Cell Signaling","I-kappaB kinase/NF-kappaB cascade","2.06E-02","HSPB1,LITAF,PLEKHG5,TFG","4"]
[]
["Cellular Assembly and Organization","microtubule dynamics","1.25E-04","ATL1,ATP7A,DCTN1,DNM2,DST,FGD4,GAN,GJB1,HSPB1,MFN2,MPZ,NDRG1,NEFL,NGF,NTRK1,PMP22,SEPT9,TRPV4,TUBB3","19"]
["Cellular Assembly and Organization","neuritogenesis of pheochromocytoma cell lines","1.55E-03","NGF,NTRK1,TRPV4","3"]
["Cellular Assembly and Organization","initiation of outgrowth of neurites","1.55E-03","NGF,NTRK1","2"]
["Cellular Assembly and Organization","formation of neurofilaments","2.73E-03","HSPB1,NEFL","2"]
["Cellular Assembly and Organization","movement of lysosome","5.56E-03","NEFL,RAB7A","2"]
["Cellular Assembly and Organization","morphology of endoplasmic reticulum","6.90E-03","ATL1,PMP22","2"]
["Cellular Assembly and Organization","formation of cellular inclusion bodies","9.34E-03","BSCL2,DNAJB2,NEFL,NGF","4"]
["Cellular Assembly and Organization","formation of cellular protrusions","1.01E-02","ATL1,ATP7A,DNM2,FGD4,HSPB1,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","12"]
["Cellular Assembly and Organization","formation of plasma membrane","1.01E-02","DNM2,GJB1,KIF1A,NGF,NTRK1,SLC5A7","6"]
["Cellular Assembly and Organization","neuritogenesis","1.08E-02","ATL1,ATP7A,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","9"]
["Cellular Assembly and Organization","neuritogenesis of neuroblastoma cell lines","1.37E-02","NGF,NTRK1","2"]
["Cellular Assembly and Organization","development of gap junctions","1.77E-02","GJB1,KIF1A,NGF,NTRK1,SLC5A7","5"]
["Cellular Assembly and Organization","elongation of filaments","1.89E-02","INF2,SEPT9","2"]
["Cellular Assembly and Organization","axonogenesis","1.99E-02","ATL1,MPZ,NGF,NTRK1,PMP22","5"]
["Cellular Assembly and Organization","myelination of axons","1.99E-02","MPZ,PMP22","2"]
["Cellular Assembly and Organization","disruption of microtubules","1.99E-02","NEFL,SEPT9","2"]
["Cellular Assembly and Organization","transport of mitochondria","1.99E-02","MFN2,NEFL","2"]
["Cellular Assembly and Organization","quantity of nerve ending","1.99E-02","NGF,NTRK1","2"]
["Cellular Assembly and Organization","morphology of nucleus","1.99E-02","AIFM1,DNMT1,LMNA","3"]
["Cellular Assembly and Organization","accumulation of caveolae","1.99E-02","DNM2","1"]
["Cellular Assembly and Organization","coalignment of microfilaments","1.99E-02","DST","1"]
["Cellular Assembly and Organization","coalignment of neurofilaments","1.99E-02","DST","1"]
["Cellular Assembly and Organization","compaction of myelin sheath","1.99E-02","MPZ","1"]
["Cellular Assembly and Organization","density of excitatory synapses","1.99E-02","MTMR2","1"]
["Cellular Assembly and Organization","detachment of desmin filament","1.99E-02","LMNA","1"]
["Cellular Assembly and Organization","disappearance of astral microtubules","1.99E-02","NDRG1","1"]
["Cellular Assembly and Organization","expansion of dendritic trees","1.99E-02","NGF","1"]
["Cellular Assembly and Organization","mobility of late endosomes","1.99E-02","RAB7A","1"]
["Cellular Assembly and Organization","outfolding of myelin sheath","1.99E-02","MTMR2","1"]
["Cellular Assembly and Organization","reassembly of GW body","1.99E-02","LMNA","1"]
["Cellular Assembly and Organization","sprouting of cholinergic fibers","1.99E-02","NGF","1"]
["Cellular Assembly and Organization","trafficking of phagosomes","1.99E-02","RAB7A","1"]
["Cellular Assembly and Organization","quantity of neurites","2.12E-02","GJB1,NEFL,NGF","3"]
["Cellular Assembly and Organization","formation of lamellipodia","2.13E-02","DNM2,FGD4,HSPB1,NGF","4"]
["Cellular Assembly and Organization","quantity of cellular protrusions","2.32E-02","FGD4,GJB1,NEFL,NGF","4"]
["Cellular Assembly and Organization","morphology of mitochondria","2.57E-02","AIFM1,GDAP1,MFN2","3"]
["Cellular Assembly and Organization","synaptogenesis","2.90E-02","KIF1A,NGF,NTRK1,SLC5A7","4"]
[]
["Cellular Compromise","degeneration of axons","5.24E-04","MFN2,MPZ,MTMR2,NGF,SLC12A6","5"]
["Cellular Compromise","endoplasmic reticulum stress response","5.78E-04","AARS,DNAJB2,DST,HSPB3,MFN2,VAPB","6"]
["Cellular Compromise","atrophy of cholinergic neurons","1.55E-03","NGF,NTRK1","2"]
["Cellular Compromise","dysfunction of neurons","6.90E-03","DNAJB2,KIF1B","2"]
["Cellular Compromise","formation of cellular inclusion bodies","9.34E-03","BSCL2,DNAJB2,NEFL,NGF","4"]
["Cellular Compromise","degeneration of neurons","1.18E-02","AIFM1,DYNC1H1,KIF1A,MPZ,NGF","5"]
["Cellular Compromise","degeneration of cells","1.99E-02","AIFM1,DYNC1H1,KIF1A,MPZ,NGF,NTRK1","6"]
["Cellular Compromise","disruption of microtubules","1.99E-02","NEFL,SEPT9","2"]
["Cellular Compromise","degeneration of Schwann cells","1.99E-02","MPZ","1"]
["Cellular Compromise","degeneration of pheochromocytoma cell lines","1.99E-02","NGF","1"]
["Cellular Compromise","disappearance of astral microtubules","1.99E-02","NDRG1","1"]
["Cellular Compromise","injury of cholinergic neurons","1.99E-02","NGF","1"]
["Cellular Compromise","fragmentation of mitochondria","2.88E-02","GDAP1,MFN2","2"]
[]
["Cellular Development","neuritogenesis of pheochromocytoma cell lines","1.55E-03","NGF,NTRK1,TRPV4","3"]
["Cellular Development","development of neurons","4.19E-03","EGR2,FIG4,KIF1A,NTRK1,PMP22,TRPV4","6"]
["Cellular Development","proliferation of fibroblast cell lines","5.64E-03","EGR2,HINT1,HSPB8,LMNA,NGF,NTRK1,SLC12A6,TFG,WNK1","9"]
["Cellular Development","neuritogenesis","1.08E-02","ATL1,ATP7A,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","9"]
["Cellular Development","myelination of neurons","1.37E-02","EGR2,PMP22","2"]
["Cellular Development","neuritogenesis of neuroblastoma cell lines","1.37E-02","NGF,NTRK1","2"]
["Cellular Development","development of ganglion cells","1.75E-02","PMP22,TRPV4","2"]
["Cellular Development","development of spinal neuron","1.89E-02","PMP22,TRPV4","2"]
["Cellular Development","differentiation of neural crest cells","1.89E-02","NGF,SOX10","2"]
["Cellular Development","axonogenesis","1.99E-02","ATL1,MPZ,NGF,NTRK1,PMP22","5"]
["Cellular Development","myelination of axons","1.99E-02","MPZ,PMP22","2"]
["Cellular Development","myelination of cells","1.99E-02","EGR2,MPZ,PMP22","3"]
["Cellular Development","development of central nervous system cells","1.99E-02","KIF1A,PMP22,TRPV4","3"]
["Cellular Development","development of satellite cells","1.99E-02","SOX10","1"]
["Cellular Development","development of trigeminal motor neurons","1.99E-02","EGR2","1"]
["Cellular Development","differentiation of sympathoadrenal precursor cells","1.99E-02","NGF","1"]
["Cellular Development","differentiation of teratoma","1.99E-02","DNMT1","1"]
["Cellular Development","expansion of Schwann cells","1.99E-02","PMP22","1"]
["Cellular Development","initiation of differentiation of neurons","1.99E-02","NGF","1"]
["Cellular Development","self-renewal of leukemia stem cells","1.99E-02","DNMT1","1"]
["Cellular Development","sprouting of cholinergic fibers","1.99E-02","NGF","1"]
["Cellular Development","proliferation of gonadal cell lines","2.06E-02","EGR2,NGF,TUBB3","3"]
["Cellular Development","proliferation of Schwann cells","2.74E-02","EGR2,PMP22","2"]
[]
["Cellular Function and Maintenance","microtubule dynamics","1.25E-04","ATL1,ATP7A,DCTN1,DNM2,DST,FGD4,GAN,GJB1,HSPB1,MFN2,MPZ,NDRG1,NEFL,NGF,NTRK1,PMP22,SEPT9,TRPV4,TUBB3","19"]
["Cellular Function and Maintenance","endoplasmic reticulum stress response","5.78E-04","AARS,DNAJB2,DST,HSPB3,MFN2,VAPB","6"]
["Cellular Function and Maintenance","axonal transport","5.99E-04","GAN,KIF1A,KIF1B,NEFL","4"]
["Cellular Function and Maintenance","function of cholinergic neurons","6.06E-04","NGF,NTRK1","2"]
["Cellular Function and Maintenance","neuritogenesis of pheochromocytoma cell lines","1.55E-03","NGF,NTRK1,TRPV4","3"]
["Cellular Function and Maintenance","formation of neurofilaments","2.73E-03","HSPB1,NEFL","2"]
["Cellular Function and Maintenance","movement of lysosome","5.56E-03","NEFL,RAB7A","2"]
["Cellular Function and Maintenance","respiration of fibroblast cell lines","8.73E-03","MFN2,TRPV4","2"]
["Cellular Function and Maintenance","formation of cellular protrusions","1.01E-02","ATL1,ATP7A,DNM2,FGD4,HSPB1,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","12"]
["Cellular Function and Maintenance","neuritogenesis","1.08E-02","ATL1,ATP7A,MFN2,MPZ,NEFL,NGF,NTRK1,PMP22,TRPV4","9"]
["Cellular Function and Maintenance","neuritogenesis of neuroblastoma cell lines","1.37E-02","NGF,NTRK1","2"]
["Cellular Function and Maintenance","development of gap junctions","1.77E-02","GJB1,KIF1A,NGF,NTRK1,SLC5A7","5"]
["Cellular Function and Maintenance","movement of organelle","1.77E-02","DNM2,NEFL,RAB7A","3"]
["Cellular Function and Maintenance","axonogenesis","1.99E-02","ATL1,MPZ,NGF,NTRK1,PMP22","5"]
["Cellular Function and Maintenance","myelination of axons","1.99E-02","MPZ,PMP22","2"]
["Cellular Function and Maintenance","disruption of microtubules","1.99E-02","NEFL,SEPT9","2"]
["Cellular Function and Maintenance","disappearance of astral microtubules","1.99E-02","NDRG1","1"]
["Cellular Function and Maintenance","endocytosis of Murine norovirus 1","1.99E-02","DNM2","1"]
["Cellular Function and Maintenance","endocytosis of riboflavin","1.99E-02","DNM2","1"]
["Cellular Function and Maintenance","hyperpolarization of monocyte-derived dendritic cells","1.99E-02","SCN9A","1"]
["Cellular Function and Maintenance","maintenance of cholinergic neurons","1.99E-02","NGF","1"]
["Cellular Function and Maintenance","self-renewal of leukemia stem cells","1.99E-02","DNMT1","1"]
["Cellular Function and Maintenance","sprouting of cholinergic fibers","1.99E-02","NGF","1"]
["Cellular Function and Maintenance","quantity of neurites","2.12E-02","GJB1,NEFL,NGF","3"]
["Cellular Function and Maintenance","formation of lamellipodia","2.13E-02","DNM2,FGD4,HSPB1,NGF","4"]
["Cellular Function and Maintenance","quantity of cellular protrusions","2.32E-02","FGD4,GJB1,NEFL,NGF","4"]
["Cellular Function and Maintenance","synaptogenesis","2.90E-02","KIF1A,NGF,NTRK1,SLC5A7","4"]
[]
["Cellular Growth and Proliferation","contact growth inhibition of bone cancer cell lines","6.06E-04","NGF,NTRK1","2"]
["Cellular Growth and Proliferation","proliferation of fibroblast cell lines","5.64E-03","EGR2,HINT1,HSPB8,LMNA,NGF,NTRK1,SLC12A6,TFG,WNK1","9"]
["Cellular Growth and Proliferation","excitation of sensory neurons","8.73E-03","NGF,SCN9A","2"]
["Cellular Growth and Proliferation","expansion of Schwann cells","1.99E-02","PMP22","1"]
["Cellular Growth and Proliferation","hyperexcitation of sensory neurons","1.99E-02","SCN9A","1"]
["Cellular Growth and Proliferation","proliferation of gonadal cell lines","2.06E-02","EGR2,NGF,TUBB3","3"]
["Cellular Growth and Proliferation","proliferation of Schwann cells","2.74E-02","EGR2,PMP22","2"]
[]
["Cellular Movement","cell movement","1.51E-02","DNM2,DST,EGR2,FBLN5,FGD4,GJB1,HARS,HSPB1,KARS,LITAF,LMNA,MPZ,NDRG1,NGF,PLEKHG5,PMP22,SCN9A,SEPT9,SLC12A6,SOX10,SPTLC1,YARS","22"]
["Cellular Movement","extravasation of plasma","1.75E-02","NGF,NTRK1","2"]
["Cellular Movement","elongation of filaments","1.89E-02","INF2,SEPT9","2"]
["Cellular Movement","cytokinesis of endothelial cell lines","1.99E-02","SEPT9","1"]
["Cellular Movement","late cytokinesis of cervical cancer cell lines","1.99E-02","SEPT9","1"]
["Cellular Movement","scattering of cervical cancer cell lines","1.99E-02","SLC12A6","1"]
["Cellular Movement","translocation of Salmonella enterica subsp. enterica serovar Typhimurium","1.99E-02","RAB7A","1"]
["Cellular Movement","scattering","3.00E-02","NGF,RAB7A,SLC12A6","3"]
[]
["DNA Replication, Recombination, and Repair","DNA damage response of melanoma cell lines","1.99E-02","SOX10","1"]
["DNA Replication, Recombination, and Repair","demethylation of genomic DNA","1.99E-02","DNMT1","1"]
["DNA Replication, Recombination, and Repair","fragmentation of heterochromatin DNA","1.99E-02","LMNA","1"]
[]
["Drug Metabolism","synthesis of norepinephrine","1.37E-02","ATP7A,NGF","2"]
["Drug Metabolism","localization of doxorubicin","1.99E-02","ATP7A","1"]
[]
["Energy Production","release of ATP","3.00E-02","GJB1,TRPV4","2"]
[]
["Gene Expression","binding of Egr binding site","1.58E-02","EGR2,NGF","2"]
["Gene Expression","demethylation of genomic DNA","1.99E-02","DNMT1","1"]
[]
["Lipid Metabolism","biosynthesis of sphinganine","6.06E-04","SPTLC1,SPTLC2","2"]
["Lipid Metabolism","production of phosphatidylinositol 3,4-diphosphate","6.06E-04","NGF,NTRK1","2"]
["Lipid Metabolism","quantity of sphingosylphosphocholine","6.06E-04","SPTLC1,SPTLC2","2"]
["Lipid Metabolism","synthesis of D-sphingosine","2.73E-03","SPTLC1,SPTLC2","2"]
["Lipid Metabolism","metabolism of phosphatidylinositol","9.06E-03","FIG4,MTMR2,NGF,NTRK1","4"]
["Lipid Metabolism","synthesis of sphingomyelin","1.37E-02","SPTLC1,SPTLC2","2"]
["Lipid Metabolism","metabolism of phospholipid","1.40E-02","FIG4,MTMR2,NGF,NTRK1,SPTLC1,SPTLC2","6"]
["Lipid Metabolism","concentration of lipid","1.67E-02","AIFM1,BSCL2,DNM2,FIG4,IFRD1,IGHMBP2,LMNA,NGF,NTRK1,RAB7A,SPTLC1,SPTLC2","12"]
["Lipid Metabolism","dephosphorylation of phosphoinositide","1.75E-02","FIG4,MTMR2","2"]
["Lipid Metabolism","concentration of phospholipid","1.85E-02","FIG4,NGF,NTRK1,SPTLC1,SPTLC2","5"]
["Lipid Metabolism","accumulation of fat","1.89E-02","IFRD1,LMNA","2"]
["Lipid Metabolism","quantity of ceramide","1.96E-02","NGF,SPTLC1,SPTLC2","3"]
["Lipid Metabolism","synthesis of phospholipid","1.99E-02","MTMR2,NGF,NTRK1,SPTLC1,SPTLC2","5"]
["Lipid Metabolism","hydrolysis of sphingomyelin","1.99E-02","NGF,NTRK1","2"]
["Lipid Metabolism","synthesis of ceramide","1.99E-02","NGF,SPTLC1,SPTLC2","3"]
["Lipid Metabolism","synthesis of phosphoinositide","1.99E-02","MTMR2,NGF,NTRK1","3"]
["Lipid Metabolism","quantity of phosphoinositide","1.99E-02","FIG4,NGF,NTRK1","3"]
[]
["Molecular Transport","quantity of sphingosylphosphocholine","6.06E-04","SPTLC1,SPTLC2","2"]
["Molecular Transport","transport of ion","1.37E-02","ATP7A,GJB1,SCN11A,SCN9A,SLC12A6,SLC5A7,SURF1,TRPV4,WNK1","9"]
["Molecular Transport","concentration of lipid","1.67E-02","AIFM1,BSCL2,DNM2,FIG4,IFRD1,IGHMBP2,LMNA,NGF,NTRK1,RAB7A,SPTLC1,SPTLC2","12"]
["Molecular Transport","concentration of phospholipid","1.85E-02","FIG4,NGF,NTRK1,SPTLC1,SPTLC2","5"]
["Molecular Transport","accumulation of fat","1.89E-02","IFRD1,LMNA","2"]
["Molecular Transport","quantity of ceramide","1.96E-02","NGF,SPTLC1,SPTLC2","3"]
["Molecular Transport","quantity of D-sphingosine","1.99E-02","SPTLC1,SPTLC2","2"]
["Molecular Transport","quantity of phosphoinositide","1.99E-02","FIG4,NGF,NTRK1","3"]
["Molecular Transport","transport of cation","1.99E-02","ATP7A,GJB1,SCN11A,SCN9A,SLC5A7,SURF1,TRPV4","7"]
["Molecular Transport","mobilization of D-glucose","1.99E-02","GJB1","1"]
["Molecular Transport","release of ATP","3.00E-02","GJB1,TRPV4","2"]
["Molecular Transport","transport of inorganic cation","3.00E-02","ATP7A,GJB1,SCN11A,SCN9A,SURF1,TRPV4","6"]
["Molecular Transport","release of acetylcholine","3.00E-02","NGF,SLC5A7","2"]
[]
["Nucleic Acid Metabolism","release of ATP","3.00E-02","GJB1,TRPV4","2"]
["Nucleic Acid Metabolism","biosynthesis of purine ribonucleotide","3.00E-02","MFN2,MT-ATP6,PRPS1","3"]
[]
["Post-Translational Modification","folding of protein","7.63E-03","AARS,DNAJB2,HSPB1,RAB7A","4"]
[]
["Protein Folding","folding of protein","7.63E-03","AARS,DNAJB2,HSPB1,RAB7A","4"]
[]
["Protein Synthesis","polymerization of protein","1.05E-02","ATL1,GJB1,IGHMBP2,MTMR2,NEFL,SBF2,SEPT9","7"]
[]
["RNA Post-Transcriptional Modification","aminoacylation of tRNA-Lys","1.99E-02","KARS","1"]
[]
["Small Molecule Biochemistry","synthesis of amine","9.20E-05","ATP7A,NGF,NTRK1,SLC5A7,SPTLC1,SPTLC2","6"]
["Small Molecule Biochemistry","synthesis of acetylcholine","9.22E-05","NGF,NTRK1,SLC5A7","3"]
["Small Molecule Biochemistry","biosynthesis of sphinganine","6.06E-04","SPTLC1,SPTLC2","2"]
["Small Molecule Biochemistry","production of phosphatidylinositol 3,4-diphosphate","6.06E-04","NGF,NTRK1","2"]
["Small Molecule Biochemistry","quantity of sphingosylphosphocholine","6.06E-04","SPTLC1,SPTLC2","2"]
["Small Molecule Biochemistry","synthesis of neurotransmitter","1.08E-03","ATP7A,NGF,NTRK1,SLC5A7","4"]
["Small Molecule Biochemistry","metabolism of neurotransmitter","2.51E-03","ATP7A,NGF,NTRK1,SLC5A7","4"]
["Small Molecule Biochemistry","synthesis of D-sphingosine","2.73E-03","SPTLC1,SPTLC2","2"]
["Small Molecule Biochemistry","metabolism of phosphatidylinositol","9.06E-03","FIG4,MTMR2,NGF,NTRK1","4"]
["Small Molecule Biochemistry","synthesis of norepinephrine","1.37E-02","ATP7A,NGF","2"]
["Small Molecule Biochemistry","synthesis of sphingomyelin","1.37E-02","SPTLC1,SPTLC2","2"]
["Small Molecule Biochemistry","metabolism of phospholipid","1.40E-02","FIG4,MTMR2,NGF,NTRK1,SPTLC1,SPTLC2","6"]
["Small Molecule Biochemistry","concentration of lipid","1.67E-02","AIFM1,BSCL2,DNM2,FIG4,IFRD1,IGHMBP2,LMNA,NGF,NTRK1,RAB7A,SPTLC1,SPTLC2","12"]
["Small Molecule Biochemistry","dephosphorylation of phosphoinositide","1.75E-02","FIG4,MTMR2","2"]
["Small Molecule Biochemistry","concentration of phospholipid","1.85E-02","FIG4,NGF,NTRK1,SPTLC1,SPTLC2","5"]
["Small Molecule Biochemistry","accumulation of fat","1.89E-02","IFRD1,LMNA","2"]
["Small Molecule Biochemistry","quantity of ceramide","1.96E-02","NGF,SPTLC1,SPTLC2","3"]
["Small Molecule Biochemistry","synthesis of phospholipid","1.99E-02","MTMR2,NGF,NTRK1,SPTLC1,SPTLC2","5"]
["Small Molecule Biochemistry","hydrolysis of sphingomyelin","1.99E-02","NGF,NTRK1","2"]
["Small Molecule Biochemistry","synthesis of ceramide","1.99E-02","NGF,SPTLC1,SPTLC2","3"]
["Small Molecule Biochemistry","synthesis of phosphoinositide","1.99E-02","MTMR2,NGF,NTRK1","3"]
["Small Molecule Biochemistry","quantity of phosphoinositide","1.99E-02","FIG4,NGF,NTRK1","3"]
["Small Molecule Biochemistry","localization of doxorubicin","1.99E-02","ATP7A","1"]
["Small Molecule Biochemistry","mobilization of D-glucose","1.99E-02","GJB1","1"]
["Small Molecule Biochemistry","release of ATP","3.00E-02","GJB1,TRPV4","2"]
["Small Molecule Biochemistry","biosynthesis of purine ribonucleotide","3.00E-02","MFN2,MT-ATP6,PRPS1","3"]
["Small Molecule Biochemistry","release of acetylcholine","3.00E-02","NGF,SLC5A7","2"]

{"sheet":"Enriched Functions","index":1,"n_rows":28,"n_cols":3,"rows_kept":28,"flags":["formulas_cached_only"]}
["© 2000-2013 Ingenuity Systems, Inc. All rights reserved."]
[]
["Enriched Functions"]
["Category"," B-H p-value","Molecules"]
["Cell Morphology","1.13E-06-2.88E-02","SEPT9,NEFL,MPZ,NGF,ATP7A,EGR2,PRX,NTRK1,FGD4,IFRD1,MFN2,DNMT1,DNM2,AIFM1,SLC12A6,ATL1,LMNA,GDAP1,GAN,PMP22,DST,TRPV4,GJB1,HSPB1,INF2"]
["Cell Death and Survival","2.66E-05-3E-02","NEFL,KIF1B,SOX10,HSPB8,SETX,MPZ,DNAJB2,NGF,ATP7A,HINT1,EGR2,KIF1A,SPTLC2,NTRK1,CCT5,VAPB,IFRD1,DNMT1,DNM2,MFN2,AIFM1,HK1,TUBB3,NDRG1,FAM134B,SURF1,LMNA,TRIM2,DYNC1H1,PMP22,YARS,DST,DCTN1,AARS,GJB1,HSPB1"]
["Small Molecule Biochemistry","9.2E-05-3E-02","MT-ATP6,SPTLC1,RAB7A,LMNA,FIG4,BSCL2,NGF,SLC5A7,ATP7A,IGHMBP2,PRPS1,SPTLC2,NTRK1,TRPV4,MTMR2,IFRD1,GJB1,MFN2,DNM2,AIFM1"]
["Cell-To-Cell Signaling and Interaction","9.22E-05-3E-02","KIF1B,SCN9A,HSPB8,MPZ,NGF,SLC5A7,ATP7A,PMP22,PRX,KIF1A,NTRK1,FGD4,TRPV4,MTMR2,GJB1,DNM2,HSPB1"]
["Cellular Assembly and Organization","1.25E-04-2.9E-02","SEPT9,NEFL,DNAJB2,MPZ,NGF,SLC5A7,ATP7A,KIF1A,NTRK1,FGD4,MTMR2,DNMT1,MFN2,DNM2,AIFM1,TUBB3,NDRG1,ATL1,RAB7A,LMNA,GDAP1,BSCL2,GAN,PMP22,DST,DCTN1,TRPV4,GJB1,INF2,HSPB1"]
["Cellular Function and Maintenance","1.25E-04-2.9E-02","HSPB3,SEPT9,NEFL,KIF1B,DNAJB2,MPZ,NGF,SLC5A7,ATP7A,KIF1A,NTRK1,FGD4,VAPB,DNMT1,MFN2,DNM2,TUBB3,NDRG1,ATL1,SCN9A,RAB7A,GAN,PMP22,DST,DCTN1,TRPV4,AARS,GJB1,HSPB1"]
["Cellular Compromise","5.24E-04-2.88E-02","HSPB3,NDRG1,SEPT9,NEFL,KIF1B,GDAP1,MPZ,DNAJB2,BSCL2,NGF,DYNC1H1,KIF1A,DST,NTRK1,MTMR2,VAPB,AARS,MFN2,AIFM1,SLC12A6"]
["Carbohydrate Metabolism","6.06E-04-1.99E-02","ATP7A,NTRK1,MTMR2,FIG4,NGF,GJB1"]
["Cell Cycle","6.06E-04-3E-02","NDRG1,SEPT9,NEFL,NTRK1,LMNA,DCTN1,WNK1,NGF,PDK3,INF2"]
["Cellular Growth and Proliferation","6.06E-04-2.74E-02","TUBB3,HINT1,PMP22,EGR2,TFG,SCN9A,NTRK1,HSPB8,LMNA,NGF,WNK1,SLC12A6"]
["Lipid Metabolism","6.06E-04-1.99E-02","SPTLC1,RAB7A,LMNA,FIG4,BSCL2,NGF,IGHMBP2,SPTLC2,NTRK1,MTMR2,IFRD1,DNM2,AIFM1"]
["Molecular Transport","6.06E-04-3E-02","SPTLC1,SCN9A,SURF1,RAB7A,LMNA,FIG4,BSCL2,NGF,ATP7A,SLC5A7,IGHMBP2,SPTLC2,NTRK1,TRPV4,WNK1,IFRD1,GJB1,SCN11A,DNM2,SLC12A6,AIFM1"]
["Cellular Development","1.55E-03-2.74E-02","TUBB3,TFG,ATL1,NEFL,SOX10,HSPB8,LMNA,FIG4,MPZ,NGF,ATP7A,PMP22,HINT1,EGR2,KIF1A,NTRK1,TRPV4,WNK1,DNMT1,MFN2,SLC12A6"]
["Post-Translational Modification","7.63E-03-7.63E-03","RAB7A,AARS,DNAJB2,HSPB1"]
["Protein Folding","7.63E-03-7.63E-03","RAB7A,AARS,DNAJB2,HSPB1"]
["Protein Synthesis","1.05E-02-1.05E-02","IGHMBP2,SEPT9,SBF2,NEFL,ATL1,MTMR2,GJB1"]
["Drug Metabolism","1.37E-02-1.99E-02","ATP7A,NGF"]
["Cellular Movement","1.51E-02-3E-02","LITAF,SPTLC1,FBLN5,NDRG1,SEPT9,SCN9A,SOX10,RAB7A,HARS,LMNA,MPZ,NGF,PMP22,EGR2,PLEKHG5,YARS,DST,NTRK1,KARS,FGD4,GJB1,DNM2,INF2,SLC12A6,HSPB1"]
["Gene Expression","1.58E-02-1.99E-02","EGR2,NGF,DNMT1"]
["Cell Signaling","1.99E-02-2.06E-02","LITAF,TFG,PLEKHG5,TRPV4,HSPB1"]
["DNA Replication, Recombination, and Repair","1.99E-02-1.99E-02","SOX10,LMNA,DNMT1"]
["RNA Post-Transcriptional Modification","1.99E-02-1.99E-02","KARS"]
["Energy Production","3E-02-3E-02","TRPV4,GJB1"]
["Nucleic Acid Metabolism","3E-02-3E-02","MT-ATP6,PRPS1,TRPV4,GJB1,MFN2"]

{"sheet":"Peripheral Neuropaty","index":2,"n_rows":5,"n_cols":3,"rows_kept":5,"flags":["formulas_cached_only"]}
["© 2000-2013 Ingenuity Systems, Inc. All rights reserved."]
[]
["Function Annotation","Molecules","# Molecules"]
["affects peripheral neuropathy (126/131)","AARS, AFG3L2, AIFM1, AIRE, ALS2, AMY2A, AMY2B, AP4B1, AP4E1, AP4M1, AP4S1, AP5Z1, AR, ATL1, BSCL2, C12orf65, CACNA1A, CACNA1B, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CD59, CHRNA1, CHRNB1, CHRND, CHRNE, CNR1, CNR2, CNTF, CST3, CYP2U1, CYP3A5, CYP7B1, DDHD1, DDHD2, DHTKD1, DNM2, DNMT1, DST, DYNC1H1, EGR2, ERLIN2, FA2H, FAM134B, FGD4, FIG4, GARS, GBA2, GDAP1, GJB1, GJB3, GJC2, HK1, HSPB1, HSPB8, HSPD1, IKBKAP, INF2, KARS, KIAA0196, KIF1A, KIF1B, KIF5A, LITAF, LMNA, LRSAM1, MED25, MFN2, MPV17, MPZ, MT-TE, MTMR2, MTPAP, MUSK, MYH14, NDRG1, NEFL, NGF, NIPA1, NR3C1, NTRK1, OPRM1, PLP1, PMP22, PNPLA6, PRPS1, PRX, RAB7A, RAPSN, REEP1, RTN2, S1PR1, S1PR3, S1PR4, S1PR5, SBF1, SBF2, SCN10A, SCN1A, SCN1B, SCN5A, SCN9A, SCP2, SEPT9, SH3TC2, SLC12A6, SLC33A1, SLC6A2, SOX10, SPAST, SPG11, SPG21, SPG7, SPTLC1, SPTLC2, SURF1, TECPR2, TFG, TRPV4, TTR, VPS37A, WNK1, YARS, ZFYVE26, ZFYVE27","126"]
["decreases peripheral neuropathy (5/131)","CD86, COX10, HIF1A, NOS1, TFAM","5"]