{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["SuppFile2"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"SuppFile2","index":0,"n_rows":108,"n_cols":24,"rows_kept":108,"flags":["formulas_cached_only"]}
["Official Symbol","GeneCards ID","Entrez Gene ID","Official Full Name","Heatmap","MAID t0t1","MAID t0t2","MAID t0t3","Mean t0","Mean t1","Mean t2","Mean t3","Down t1","Up t1","Down t2","Up t2","Down t3","Up t3","P-value t0t1","P-value t0t2","P-value t0t3","GSE24427","GSE33464","Official Symbol"]
["AHR","GC07P017304",196,"aryl hydrocarbon receptor",70,"Down",null,null,2306,1620,2918,2363,4,1,1,3,1,0,{"v":0.29931363196910504,"d":"0.299"},{"v":0.28313166073391,"d":"0.283"},{"v":0.877601888686052,"d":"0.878"},false,false,"AHR"]
["ANKRD22","GC10M090572",118932,"ankyrin repeat domain 22",26,null,null,"Up",201,284,313,1011,0,1,0,1,0,4,{"v":0.161870802604748,"d":"0.162"},{"v":0.0299493345791606,"d":"0.030"},{"v":0.23227458605637902,"d":"0.232"},true,false,"ANKRD22"]
["APOBEC3A","GC22P039348",200315,"apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A",30,null,null,"Up",1236,1749,1256,3285,0,3,1,2,0,5,{"v":0.0105127622160973,"d":"0.011"},{"v":0.9393401123839471,"d":"0.939"},{"v":0.008160385871098411,"d":"0.008"},true,true,"APOBEC3A"]
["APOBEC3B","GC22P039378",9582,"apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B",65,null,null,"Up",253,332,272,779,0,1,0,0,0,4,{"v":0.255109767609083,"d":"0.255"},{"v":0.709277557986241,"d":"0.709"},{"v":0.125308230321866,"d":"0.125"},false,true,"APOBEC3B"]
["C10orf82","GC10M118413",143379,"chromosome 10 open reading frame 82",77,"Down",null,null,268,124,262,208,4,0,2,1,0,0,{"v":0.038942777356474896,"d":"0.039"},{"v":0.9377503323110231,"d":"0.938"},{"v":0.233477050198435,"d":"0.233"},false,false,"C10orf82"]
["C3AR1","GC12M008210",719,"complement component 3a receptor 1",55,"Up",null,null,2058,2983,2280,3272,0,4,0,1,0,3,{"v":0.08860505326288849,"d":"0.089"},{"v":0.17140143005020703,"d":"0.171"},{"v":0.0725560867511899,"d":"0.073"},true,true,"C3AR1"]
["CCL2","GC17P032582",6347,"chemokine (C-C motif) ligand 2",58,null,null,"Up",89,135,23,422,0,1,0,0,0,4,{"v":0.337535136849815,"d":"0.338"},{"v":0.0436401895054981,"d":"0.044"},{"v":0.0510750863183808,"d":"0.051"},true,true,"CCL2"]
["CD163","GC12M007523",9332,"CD163 molecule",93,"Up","Up",null,1852,3748,3987,1898,0,4,0,4,0,1,{"v":0.021642512977553298,"d":"0.022"},{"v":0.0881116576516522,"d":"0.088"},{"v":0.8278203064797961,"d":"0.828"},true,true,"CD163"]
["CD38","GC04P015779",952,"CD38 molecule",20,"Up",null,"Up",464,775,621,878,0,4,0,0,0,4,{"v":0.0520502991537044,"d":"0.052"},{"v":0.0700842191764556,"d":"0.070"},{"v":0.0104034906006167,"d":"0.010"},true,false,"CD38"]
["CD83","GC06P014117",9308,"CD83 molecule",94,null,"Down",null,829,719,430,699,1,0,4,0,1,0,{"v":0.323364865972656,"d":"0.323"},{"v":0.022222029731266798,"d":"0.022"},{"v":0.44129849056191706,"d":"0.441"},false,false,"CD83"]
["CDKN1C","GC11M002861",1028,"cyclin-dependent kinase inhibitor 1C (p57, Kip2)",71,null,"Down",null,901,779,484,924,1,0,4,0,0,0,{"v":0.24652074058580403,"d":"0.247"},{"v":0.0144781183977938,"d":"0.014"},{"v":0.8483910555935511,"d":"0.848"},false,false,"CDKN1C"]
["CHMP5","GC09P033257",51510,"chromatin modifying protein 5",44,null,null,"Up",1827,2127,1970,2944,0,1,0,0,0,4,{"v":0.0880857285805085,"d":"0.088"},{"v":0.211805242672813,"d":"0.212"},{"v":0.0040800909469985,"d":"0.004"},true,false,"CHMP5"]
["CLC","GC19M040221",1178,"Charcot-Leyden crystal protein",80,null,null,"Down",2415,2062,2407,1081,1,0,2,1,4,0,{"v":0.0850355539146736,"d":"0.085"},{"v":0.988177886403601,"d":"0.988"},{"v":0.0421903091077062,"d":"0.042"},true,false,"CLC"]
["CLEC4E","GC12M008685",26253,"C-type lectin domain family 4, member E",62,null,"Up",null,1012,1268,1551,1207,0,1,0,4,0,2,{"v":0.0908905481534225,"d":"0.091"},{"v":0.022423883082335498,"d":"0.022"},{"v":0.248424180302578,"d":"0.248"},true,false,"CLEC4E"]
["CMPK2","GC02M006980",129607,"cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial",2,null,null,"Up",944,1603,1361,5020,0,3,0,2,0,6,{"v":0.05648903865029901,"d":"0.056"},{"v":0.028263190387907002,"d":"0.028"},{"v":0.0014415746742901402,"d":"0.001"},true,true,"CMPK2"]
["CTSL1","GC09P090341",1514,"cathepsin L1",43,null,null,"Up",611,839,639,1189,0,1,0,0,0,4,{"v":0.0224913946195186,"d":"0.022"},{"v":0.595426568718153,"d":"0.595"},{"v":0.0017138385257160999,"d":"0.002"},false,false,"CTSL1"]
["CXCL10","GC04M076942",3627,"chemokine (C-X-C motif) ligand 10",27,null,null,"Up",226,281,206,1874,0,0,1,0,0,4,{"v":0.12353326079263,"d":"0.124"},{"v":0.74243079238148,"d":"0.742"},{"v":0.265481724316925,"d":"0.265"},true,true,"CXCL10"]
["CXCR4","GC02M136894",7852,"chemokine (C-X-C motif) receptor 4",73,null,"Up",null,5977,5177,10738,6310,1,0,0,4,0,1,{"v":0.31699721711620504,"d":"0.317"},{"v":0.034583966385710097,"d":"0.035"},{"v":0.660090401046528,"d":"0.660"},false,false,"CXCR4"]
["DDIT4","GC10P074033",54541,"DNA-damage-inducible transcript 4",63,null,"Up",null,1228,1487,5571,1893,1,3,1,5,0,3,{"v":0.540488181347985,"d":"0.540"},{"v":0.0230572189569412,"d":"0.023"},{"v":0.14869717386998701,"d":"0.149"},false,false,"DDIT4"]
["DDX60","GC04M169137",55601,"DEAD (Asp-Glu-Ala-Asp) box polypeptide 60",12,null,null,"Up",1351,1603,1611,2920,0,1,0,1,0,4,{"v":0.12914710682480002,"d":"0.129"},{"v":0.288352366055933,"d":"0.288"},{"v":0.00804842706313357,"d":"0.008"},true,true,"DDX60"]
["DDX60L","GC04M169277",91351,"DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like",29,null,null,"Up",688,851,775,1190,0,1,0,1,0,4,{"v":0.0218433923770575,"d":"0.022"},{"v":0.282973667968131,"d":"0.283"},{"v":0.0173885177364798,"d":"0.017"},true,false,"DDX60L"]
["DUSP6","GC12M089741",1848,"dual specificity phosphatase 6",85,null,"Down",null,11126,11112,7129,10197,0,0,4,0,1,0,{"v":0.9921583183621391,"d":"0.992"},{"v":0.0186916144066946,"d":"0.019"},{"v":0.6064161570731811,"d":"0.606"},true,false,"DUSP6"]
["EGR1","GC05P137801",1958,"early growth response 1",86,null,"Down",null,1846,2213,1132,1903,1,2,4,0,1,1,{"v":0.38695785694212903,"d":"0.387"},{"v":0.0393344278516115,"d":"0.039"},{"v":0.876772266164471,"d":"0.877"},false,true,"EGR1"]
["EGR2","GC10M064571",1959,"early growth response 2",89,null,"Down",null,1037,1337,352,959,1,1,5,0,1,0,{"v":0.323938445833718,"d":"0.324"},{"v":0.00761831289579362,"d":"0.008"},{"v":0.665939751577988,"d":"0.666"},false,true,"EGR2"]
["EPSTI1","GC13M043460",94240,"epithelial stromal interaction 1 (breast)",4,null,null,"Up",982,1473,1236,3656,0,2,0,1,0,6,{"v":0.0646036952387081,"d":"0.065"},{"v":0.0536575048989832,"d":"0.054"},{"v":0.00365691477970396,"d":"0.004"},true,true,"EPSTI1"]
["FCER1A","GC01P159259",2205,"Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide",81,"Down","Down","Down",3205,1869,2070,1695,5,0,4,0,6,0,{"v":0.0182294243900585,"d":"0.018"},{"v":0.0327077300888153,"d":"0.033"},{"v":0.000691091366295419,"d":"0.001"},true,true,"FCER1A"]
["FKBP5","GC06M035541",2289,"FK506 binding protein 5",54,null,"Up",null,940,1101,1759,1450,0,1,0,4,0,3,{"v":0.264044617240758,"d":"0.264"},{"v":0.0126801246221061,"d":"0.013"},{"v":0.0036496680713920503,"d":"0.004"},true,false,"FKBP5"]
["GBP1","GC01M089517",2633,"guanylate binding protein 1, interferon-inducible, 67kDa",25,null,null,"Up",2121,2020,1803,5855,1,0,1,0,0,4,{"v":0.586475591602656,"d":"0.586"},{"v":0.14648096565715302,"d":"0.146"},{"v":0.18987883122777102,"d":"0.190"},true,true,"GBP1"]
["GZMB","GC14M025100",3002,"granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)",61,null,null,"Up",5628,6626,6669,9461,0,1,0,1,0,4,{"v":0.0178417477082,"d":"0.018"},{"v":0.09351915209045901,"d":"0.094"},{"v":0.0178763012689146,"d":"0.018"},true,true,"GZMB"]
["HBA1","GC16P000241",3039,"hemoglobin, alpha 1",68,null,"Up",null,3365,4858,8715,3350,0,2,0,4,3,1,{"v":0.17049367325383702,"d":"0.170"},{"v":0.053298489898653004,"d":"0.053"},{"v":0.9909062337948361,"d":"0.991"},false,false,"HBA1"]
["HBA2","GC16P000244",3040,"hemoglobin, alpha 2",67,null,"Up",null,12559,18110,28403,13235,0,2,0,4,3,1,{"v":0.22998176709605903,"d":"0.230"},{"v":0.0421749155772672,"d":"0.042"},{"v":0.8743860911001421,"d":"0.874"},false,false,"HBA2"]
["HBB","GC11M005250",3043,"hemoglobin, beta",66,null,"Up",null,31577,40712,54460,29279,0,2,0,4,2,1,{"v":0.09244694978767509,"d":"0.092"},{"v":0.0376508367409907,"d":"0.038"},{"v":0.766931751788531,"d":"0.767"},true,false,"HBB"]
["HBD","GC11M005251",3045,"hemoglobin, delta",69,null,"Up",null,390,541,911,312,0,2,0,4,1,0,{"v":0.149517313605277,"d":"0.150"},{"v":0.0410219401557702,"d":"0.041"},{"v":0.6964424928038051,"d":"0.696"},false,false,"HBD"]
["HERC5","GC04P089378",51191,"hect domain and RLD 5",19,null,null,"Up",815,1093,1076,2697,0,1,0,1,0,6,{"v":0.21565526899629903,"d":"0.216"},{"v":0.05181094394940101,"d":"0.052"},{"v":0.00103517442719478,"d":"0.001"},true,true,"HERC5"]
["HERC6","GC04P089299",55008,"hect domain and RLD 6",34,null,null,"Up",662,772,820,1483,0,1,0,0,0,5,{"v":0.29106198989507204,"d":"0.291"},{"v":0.0472068943370755,"d":"0.047"},{"v":0.0029113701545127103,"d":"0.003"},true,true,"HERC6"]
["IFI27","GC14P094577",3429,"interferon, alpha-inducible protein 27",17,null,"Up","Up",32,306,330,3057,0,3,0,4,0,6,{"v":0.0695350701564868,"d":"0.070"},{"v":0.0243853512902009,"d":"0.024"},{"v":0.0122653827951536,"d":"0.012"},true,true,"IFI27"]
["IFI35","GC17P041158",3430,"interferon-induced protein 35",15,null,null,"Up",875,1064,858,1816,0,0,0,0,0,5,{"v":0.121702895060266,"d":"0.122"},{"v":0.794174270629301,"d":"0.794"},{"v":0.00826569964028382,"d":"0.008"},true,true,"IFI35"]
["IFI44","GC01P079115",10561,"interferon-induced protein 44",7,null,"Up","Up",1456,2882,2375,7189,0,3,0,4,0,6,{"v":0.044552432639154003,"d":"0.045"},{"v":0.00223393536846465,"d":"0.002"},{"v":0.00067868617713157,"d":"0.001"},true,true,"IFI44"]
["IFI44L","GC01P079085",10964,"interferon-induced protein 44-like",6,"Up","Up","Up",1089,3034,2536,10615,0,4,0,5,0,6,{"v":0.0272118606281716,"d":"0.027"},{"v":0.00603470037485312,"d":"0.006"},{"v":0.000655743793996787,"d":"0.001"},true,true,"IFI44L"]
["IFI6","GC01M027992",2537,"interferon, alpha-inducible protein 6",8,"Up","Up","Up",2246,5222,3597,11317,0,4,0,4,0,6,{"v":0.0287321454533009,"d":"0.029"},{"v":0.0093443838785638,"d":"0.009"},{"v":0.00174338724194862,"d":"0.002"},true,true,"IFI6"]
["IFIH1","GC02M163123",64135,"interferon induced with helicase C domain 1",42,null,null,"Up",524,599,587,1008,0,1,0,0,0,5,{"v":0.25969939813653603,"d":"0.260"},{"v":0.24709848209666702,"d":"0.247"},{"v":0.0021332758062969203,"d":"0.002"},true,false,"IFIH1"]
["IFIT1","GC10P091142",3434,"interferon-induced protein with tetratricopeptide repeats 1",32,null,"Up","Up",634,1384,962,5836,1,3,0,4,0,6,{"v":0.147350701620343,"d":"0.147"},{"v":0.0665185437251604,"d":"0.067"},{"v":0.0011198328169214,"d":"0.001"},true,true,"IFIT1"]
["IFIT2","GC10P091051",3433,"interferon-induced protein with tetratricopeptide repeats 2",16,null,null,"Up",478,629,459,1551,0,1,0,0,0,6,{"v":0.0660679269197306,"d":"0.066"},{"v":0.406380721254103,"d":"0.406"},{"v":0.015688324036715398,"d":"0.016"},true,true,"IFIT2"]
["IFIT3","GC10P091077",3437,"interferon-induced protein with tetratricopeptide repeats 3",1,"Up",null,"Up",907,1969,1278,6382,0,4,0,2,0,6,{"v":0.0402099171778116,"d":"0.040"},{"v":0.0528542099641586,"d":"0.053"},{"v":0.0032594394711357904,"d":"0.003"},true,true,"IFIT3"]
["IFIT5","GC10P091164",24138,"interferon-induced protein with tetratricopeptide repeats 5",45,null,null,"Up",596,753,720,1180,0,1,0,1,0,6,{"v":0.037386044321462,"d":"0.037"},{"v":0.08300042389707529,"d":"0.083"},{"v":9.082644307682619e-05,"d":"0.000"},true,true,"IFIT5"]
["IFITM1","GC11P000303",8519,"interferon induced transmembrane protein 1 (9-27)",51,null,null,"Up",20527,21973,22931,33946,0,1,0,0,0,4,{"v":0.428621776782506,"d":"0.429"},{"v":0.0666853908976201,"d":"0.067"},{"v":0.00631690545896974,"d":"0.006"},true,false,"IFITM1"]
["IFITM2","GC11P000300",10581,"interferon induced transmembrane protein 2 (1-8D)",46,null,null,"Up",11637,14348,12670,21061,0,1,0,0,0,6,{"v":0.039997617908363,"d":"0.040"},{"v":0.296818996986904,"d":"0.297"},{"v":0.0017910375194289602,"d":"0.002"},false,false,"IFITM2"]
["IFITM3","GC11M000309",10410,"interferon induced transmembrane protein 3 (1-8U)",14,"Up",null,"Up",2973,6867,4298,15277,0,4,0,3,0,6,{"v":0.0226046417778818,"d":"0.023"},{"v":0.09195381563056179,"d":"0.092"},{"v":0.005992687767751781,"d":"0.006"},false,false,"IFITM3"]
["IGJ","GC04M071478",3512,"immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides",64,"Up","Up",null,8432,16728,14325,11225,0,4,0,4,0,2,{"v":0.17207674258401,"d":"0.172"},{"v":0.0175813059746753,"d":"0.018"},{"v":0.10823772734926101,"d":"0.108"},false,false,"IGJ"]
["IL1B","GC02M113682",3553,"interleukin 1, beta",92,null,"Down",null,1064,789,457,912,2,0,5,0,2,0,{"v":0.011616838484246099,"d":"0.012"},{"v":0.000815979681295231,"d":"0.001"},{"v":0.36244489153962806,"d":"0.362"},false,false,"IL1B"]
["IL1R2","GC02P102608",7850,"interleukin 1 receptor, type II",88,null,"Up",null,147,239,593,84,0,2,0,4,0,0,{"v":0.14118077785771302,"d":"0.141"},{"v":0.0663012381046881,"d":"0.066"},{"v":0.126185116011846,"d":"0.126"},true,false,"IL1R2"]
["IL8","GC04P074595",3576,"interleukin 8",91,null,"Down",null,674,436,396,367,2,0,4,0,3,0,{"v":0.0627121346318178,"d":"0.063"},{"v":0.0166326151890234,"d":"0.017"},{"v":0.0378794773714892,"d":"0.038"},true,true,"IL8"]
["IRF7","GC11M000602",3665,"interferon regulatory factor 7",40,null,null,"Up",1181,1519,1246,2536,0,2,0,0,0,6,{"v":0.0276962582403372,"d":"0.028"},{"v":0.5146810447457091,"d":"0.515"},{"v":0.0023657206944372997,"d":"0.002"},true,true,"IRF7"]
["ISG15","GC01P000938",9636,"ISG15 ubiquitin-like modifier",48,null,null,"Up",3888,5934,5163,16763,0,2,0,3,0,6,{"v":0.0944522089149733,"d":"0.094"},{"v":0.0532591586402751,"d":"0.053"},{"v":0.00335687056912588,"d":"0.003"},true,true,"ISG15"]
["ITGAE","GC17M003564",3682,"integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)",78,null,null,"Down",3072,2785,2808,1954,0,0,1,0,4,0,{"v":0.24521839084538,"d":"0.245"},{"v":0.36704850393596605,"d":"0.367"},{"v":0.004837422941215331,"d":"0.005"},false,false,"ITGAE"]
["JUNB","GC19P012902",3726,"jun B proto-oncogene",83,null,"Down",null,3217,3290,2114,2765,0,0,4,0,1,0,{"v":0.780198097174374,"d":"0.780"},{"v":0.025129447248892003,"d":"0.025"},{"v":0.457633468832824,"d":"0.458"},false,false,"JUNB"]
["LAP3","GC04P017578",51056,"leucine aminopeptidase 3",22,null,null,"Up",2865,3258,2703,7477,0,2,0,0,0,6,{"v":0.323288192275183,"d":"0.323"},{"v":0.48743535301620206,"d":"0.487"},{"v":0.0698308861371771,"d":"0.070"},false,true,"LAP3"]
["LGALS2","GC22M037966",3957,"lectin, galactoside-binding, soluble, 2",90,null,"Down",null,5459,4664,3387,5513,2,0,4,0,0,1,{"v":0.41940132027589505,"d":"0.419"},{"v":0.0427113915131093,"d":"0.043"},{"v":0.9475970225563711,"d":"0.948"},true,false,"LGALS2"]
["LGALS3BP","GC17M076970",3959,"lectin, galactoside-binding, soluble, 3 binding protein",38,null,null,"Up",263,335,269,619,0,1,0,0,0,5,{"v":0.17619143298648102,"d":"0.176"},{"v":0.7557869567353871,"d":"0.756"},{"v":0.0030135015418516604,"d":"0.003"},true,true,"LGALS3BP"]
["LINGO3","GC19M002289",645191,"leucine rich repeat and Ig domain containing 3",84,null,"Down",null,417,286,210,266,2,0,4,0,3,0,{"v":0.0962245801915072,"d":"0.096"},{"v":0.0276140917889425,"d":"0.028"},{"v":0.15184474277613202,"d":"0.152"},false,false,"LINGO3"]
["LOC391020","GC01M025196",391020,null,13,null,null,"Up",569,690,658,1509,0,1,0,1,0,6,{"v":0.415822789146614,"d":"0.416"},{"v":0.44776669144233106,"d":"0.448"},{"v":0.0025170828188657303,"d":"0.003"},false,true,"LOC391020"]
["LTF","GC03M046452",4057,"lactotransferrin",82,null,"Up",null,1966,2394,5606,1670,0,2,0,4,3,2,{"v":0.38057784071204603,"d":"0.381"},{"v":0.228812892232193,"d":"0.229"},{"v":0.5731559720332511,"d":"0.573"},false,false,"LTF"]
["LY6E","GC08P144171",4061,"lymphocyte antigen 6 complex, locus E",50,null,null,"Up",234,314,257,673,0,1,0,1,0,6,{"v":0.356496550897195,"d":"0.356"},{"v":0.67150789985792,"d":"0.672"},{"v":0.00223786835482859,"d":"0.002"},true,true,"LY6E"]
["MARCKS","GC06P114224",4082,"myristoylated alanine-rich protein kinase C substrate",53,null,null,"Up",810,918,621,1360,0,0,1,0,0,4,{"v":0.30959803368536104,"d":"0.310"},{"v":0.056306810900357,"d":"0.056"},{"v":0.00029633255322556004,"d":"0.000"},true,false,"MARCKS"]
["MS4A4A","GC11P060048",51338,"membrane-spanning 4-domains, subfamily A, member 4",49,null,null,"Up",454,715,479,987,0,2,0,0,0,5,{"v":0.0267591234482614,"d":"0.027"},{"v":0.6061754668478571,"d":"0.606"},{"v":0.0005038324171496811,"d":"0.001"},true,true,"MS4A4A"]
["MT2A","GC16P056642",4502,"metallothionein 2A",41,null,null,"Up",3892,5747,5845,9700,0,2,0,3,0,6,{"v":0.0812709254240081,"d":"0.081"},{"v":0.09504200565792689,"d":"0.095"},{"v":0.0168807063645808,"d":"0.017"},false,false,"MT2A"]
["MX1","GC21P042792",4599,"myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)",31,null,"Up","Up",1436,2541,2300,7093,0,3,0,4,0,6,{"v":0.054312328750096096,"d":"0.054"},{"v":0.0244676179467276,"d":"0.024"},{"v":0.000702010718600281,"d":"0.001"},true,true,"MX1"]
["MX2","GC21P042734",4600,"myxovirus (influenza virus) resistance 2 (mouse)",37,null,null,"Up",1366,1759,1550,3024,0,1,0,0,0,5,{"v":0.0167969919207526,"d":"0.017"},{"v":0.0349506283136809,"d":"0.035"},{"v":0.004302545604004991,"d":"0.004"},true,true,"MX2"]
["NELL2","GC12M044981",4753,"NEL-like 2 (chicken)",95,"Down",null,null,3107,2001,3243,2656,4,0,0,1,0,0,{"v":0.0138505916307391,"d":"0.014"},{"v":0.709482897324837,"d":"0.709"},{"v":0.22866851050317502,"d":"0.229"},false,false,"NELL2"]
["NEXN","GC01P078354",91624,"nexilin (F actin binding protein)",52,"Up",null,"Up",645,1168,808,1228,0,4,0,1,0,4,{"v":0.0136348470051728,"d":"0.014"},{"v":0.30630326320107304,"d":"0.306"},{"v":0.007557453886273941,"d":"0.008"},true,false,"NEXN"]
["NRGN","GC11P124643",4900,"neurogranin (protein kinase C substrate, RC3)",75,null,null,"Down",6041,8414,8699,4341,1,2,0,2,4,0,{"v":0.23914483933133,"d":"0.239"},{"v":0.13722217370093,"d":"0.137"},{"v":0.0162620519421439,"d":"0.016"},true,false,"NRGN"]
["OAS1","GC12P113344",4938,"2',5'-oligoadenylate synthetase 1, 40/46kDa",28,null,null,"Up",1530,2169,1617,4070,0,3,0,0,0,6,{"v":0.0188814251197767,"d":"0.019"},{"v":0.329519412888637,"d":"0.330"},{"v":0.00996457580790616,"d":"0.010"},true,true,"OAS1"]
["OAS2","GC12P113416",4939,"2'-5'-oligoadenylate synthetase 2, 69/71kDa",47,null,null,"Up",553,616,502,965,0,0,0,0,0,4,{"v":0.203895436517315,"d":"0.204"},{"v":0.129211760094556,"d":"0.129"},{"v":0.0015861979092802402,"d":"0.002"},true,true,"OAS2"]
["OAS3","GC12P113376",4940,"2'-5'-oligoadenylate synthetase 3, 100kDa",57,null,null,"Up",495,691,568,1432,0,2,0,0,0,6,{"v":0.17470914379952301,"d":"0.175"},{"v":0.305990163671831,"d":"0.306"},{"v":0.0024036063915193803,"d":"0.002"},true,true,"OAS3"]
["OASL","GC12M121459",8638,"2'-5'-oligoadenylate synthetase-like",33,null,null,"Up",374,537,425,1066,0,1,0,0,0,6,{"v":0.0145456848264359,"d":"0.015"},{"v":0.24781648560413802,"d":"0.248"},{"v":0.00140133734085008,"d":"0.001"},true,true,"OASL"]
["PARP9","GC03M122246",83666,"poly (ADP-ribose) polymerase family, member 9",9,null,null,"Up",884,1118,997,2262,0,1,0,0,0,6,{"v":0.108528030696419,"d":"0.109"},{"v":0.0369082261392695,"d":"0.037"},{"v":0.0125519095360864,"d":"0.013"},true,true,"PARP9"]
["PAX5","GC09M036828",5079,"paired box 5",79,null,null,"Down",271,165,230,68,2,0,0,0,5,0,{"v":0.082116152532632,"d":"0.082"},{"v":0.29571548870872605,"d":"0.296"},{"v":0.00579462503413218,"d":"0.006"},false,false,"PAX5"]
["PLAC8","GC04M083935",51316,"placenta-specific 8",18,null,null,"Up",15373,17413,16579,25206,0,1,0,0,0,4,{"v":0.108929143775883,"d":"0.109"},{"v":0.15782301431778,"d":"0.158"},{"v":0.0070483332771593705,"d":"0.007"},true,false,"PLAC8"]
["PLSCR1","GC03M146232",5359,"phospholipid scramblase 1",39,null,null,"Up",3019,3586,3400,7482,0,1,0,1,0,6,{"v":0.189376549378718,"d":"0.189"},{"v":0.10147220025647401,"d":"0.101"},{"v":0.000359775676154417,"d":"0.000"},true,true,"PLSCR1"]
["POM121L9P","GC22P024649",29774,"POM121 membrane glycoprotein-like 9 (rat) pseudogene",59,null,null,"Up",152,366,420,488,0,3,0,3,0,4,{"v":0.00803953422833616,"d":"0.008"},{"v":0.11820279380778301,"d":"0.118"},{"v":0.0179835262321312,"d":"0.018"},false,false,"POM121L9P"]
["RPL7","GC08M074252",6129,"ribosomal protein L7",60,null,null,"Up",464,591,407,804,0,2,2,2,1,4,{"v":0.298744854678342,"d":"0.299"},{"v":0.78821977663258,"d":"0.788"},{"v":0.176198103777077,"d":"0.176"},false,false,"RPL7"]
["RSAD2","GC02P007005",91543,"radical S-adenosyl methionine domain containing 2",11,null,"Up","Up",328,609,626,2167,0,3,0,4,0,6,{"v":0.051303588252084004,"d":"0.051"},{"v":0.00784092847144415,"d":"0.008"},{"v":0.0023517904902850503,"d":"0.002"},true,true,"RSAD2"]
["RTP4","GC03P187086",64108,"receptor (chemosensory) transporter protein 4",56,null,null,"Up",358,443,317,854,1,1,1,0,0,5,{"v":0.38374945155938806,"d":"0.384"},{"v":0.5265771766807981,"d":"0.527"},{"v":0.0335881111007133,"d":"0.034"},true,true,"RTP4"]
["SAMD9L","GC07M092759",219285,"sterile alpha motif domain containing 9-like",3,null,null,"Up",1159,1422,1241,2390,0,1,0,0,0,5,{"v":0.0821445105139623,"d":"0.082"},{"v":0.23210096453443702,"d":"0.232"},{"v":0.0032372552000196203,"d":"0.003"},true,true,"SAMD9L"]
["SCO2","GC22M050961",9997,"SCO cytochrome oxidase deficient homolog 2 (yeast)",24,null,null,"Up",2338,2796,1795,5057,0,1,2,0,0,4,{"v":0.24704808602463701,"d":"0.247"},{"v":0.0457036876826138,"d":"0.046"},{"v":0.0546521104449038,"d":"0.055"},true,true,"SCO2"]
["SESN1","GC06M109353",27244,"sestrin 1",72,null,"Up",null,1062,1283,2445,1166,0,1,0,5,0,0,{"v":0.17269983438372,"d":"0.173"},{"v":0.0110811368639578,"d":"0.011"},{"v":0.19059258539600302,"d":"0.191"},false,false,"SESN1"]
["SH3BGRL2","GC06P080397",83699,"SH3 domain binding glutamic acid-rich protein like 2",76,null,null,"Down",1256,1821,1939,864,0,1,0,3,4,0,{"v":0.320101623303701,"d":"0.320"},{"v":0.20802579644984,"d":"0.208"},{"v":0.0188805317055257,"d":"0.019"},true,true,"SH3BGRL2"]
["SIGLEC1","GC20M003616",6614,"sialic acid binding Ig-like lectin 1, sialoadhesin",5,"Up","Up","Up",178,698,410,1480,0,5,0,4,0,6,{"v":0.0119519459745635,"d":"0.012"},{"v":0.000526761006321073,"d":"0.001"},{"v":0.000903757341234024,"d":"0.001"},true,true,"SIGLEC1"]
["STAT1","GC02M191829",6772,"signal transducer and activator of transcription 1, 91kDa",23,null,null,"Up",2742,2883,2331,6749,1,1,1,0,0,5,{"v":0.741937349144779,"d":"0.742"},{"v":0.12563520785263202,"d":"0.126"},{"v":0.0632526802213407,"d":"0.063"},true,true,"STAT1"]
["TNFSF10","GC03M172223",8743,"tumor necrosis factor (ligand) superfamily, member 10",21,null,null,"Up",4878,5574,4415,9775,0,1,0,0,0,4,{"v":0.17990045557523301,"d":"0.180"},{"v":0.0742899044892433,"d":"0.074"},{"v":0.073501621717622,"d":"0.074"},true,false,"TNFSF10"]
["TRIM22","GC11P005667",10346,"tripartite motif-containing 22",10,null,null,"Up",7343,8137,9130,12674,0,0,0,0,0,4,{"v":0.0613686315639878,"d":"0.061"},{"v":0.0147392538643446,"d":"0.015"},{"v":0.0063737740962917,"d":"0.006"},true,false,"TRIM22"]
["TSC22D3","GC0XM106956",1831,"TSC22 domain family, member 3",87,null,"Up",null,5217,5318,10020,4843,1,1,0,4,1,0,{"v":0.9256293237819121,"d":"0.926"},{"v":0.0412885663947757,"d":"0.041"},{"v":0.606484135092728,"d":"0.606"},false,false,"TSC22D3"]
["TUBA1A","GC12M049578",7846,"tubulin, alpha 1a",74,null,"Down",null,12961,12012,8382,11132,0,0,4,0,1,0,{"v":0.20414472531691302,"d":"0.204"},{"v":0.0036267049084927304,"d":"0.004"},{"v":0.07899805369904189,"d":"0.079"},false,false,"TUBA1A"]
["USP18","GC22P018632",11274,"ubiquitin specific peptidase 18",36,null,null,"Up",368,381,433,901,0,0,0,1,0,5,{"v":0.8383884520192321,"d":"0.838"},{"v":0.36361861718453103,"d":"0.364"},{"v":0.0014910115434361101,"d":"0.001"},false,false,"USP18"]
["XAF1","GC17P006659",54739,"XIAP associated factor 1",35,null,null,"Up",2104,3135,2921,6068,0,3,0,3,0,6,{"v":0.0569031542847274,"d":"0.057"},{"v":0.0169501006489414,"d":"0.017"},{"v":0.0023696671116312,"d":"0.002"},true,true,"XAF1"]
[]
["Legends","This is the gene identifier according to the GeneCards database, version 3.03",null,null,"In the heat map (figure 2) the data of each gene are visualized in a row that is given here",{"$nulls":7},"The number of patients that showed a strong up- or down-regulation (|MAID|>2.0) at this time point compared to baseline"]
[{"$nulls":13},"The gene was filtered because at least 4 patients showed a strong change in expression"]
[{"$nulls":5},"The filtering result is summarized here according to the following scheme"]
[{"$nulls":5},"Up","The gene was filtered as up-regulated at this time point in comparison to baseline",{"$nulls":11},"The p-values of the paired t-tests comparing the expression during therapy versus baseline"]
[{"$nulls":6},"The average expression of this gene was just higher at this time point compared to the mean pre-treatment level",{"$nulls":12},"The gene was differentially expressed with p-value<0.05"]
[{"$nulls":6},"The average expression of this gene was just lower at this time point compared to the mean pre-treatment level"]
[{"$nulls":5},"Down","The gene was filtered as down-regulated at this time point in comparison to baseline",{"$nulls":14},"If true, the gene was described to be differentially expressed in response to IFN-beta-1b sc. therapy in (Goertsches et al., 2010, GEO database: GSE24427)"]
[{"$nulls":5},"t0 = baseline"]
[{"$nulls":5},"t1 = day 2",null,null,"The average expression over all patients per time point and gene",{"$nulls":13},"If true, the gene was described to be differentially expressed in response to IFN-beta-1a sc. therapy in (Hecker et al., 2013, GEO database: GSE33464)"]
[{"$nulls":5},"t2 = day 4"]
[{"$nulls":5},"t3 = month 1"]