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{"sheet":"SuppFile3","index":0,"n_rows":32,"n_cols":30,"rows_kept":32,"flags":["formulas_cached_only"]}
["Mature miRNA","TaqMan Detector","Card","MAID t0t1","MAID t0t2","MAID t0t3","Mean Ct t0","Mean Ct t1","Mean Ct t2","Mean Ct t3","Mean linear t0","Mean linear t1","Mean linear t2","Mean linear t3","Down t1","Up t1","Down t2","Up t2","Down t3","Up t3","P-value t0t1","P-value t0t2","P-value t0t3","Val Affy Mean t0","Val Affy Mean t3","Val Affy Diff","Val PCR Mean t0","Val PCR Mean t3","Val PCR Diff","Mature miRNA"]
["hsa-let-7a-5p","hsa-let-7a-4373169","A",null,null,"Up",{"v":22.9806213333333,"d":"22.98"},{"v":22.7467388333333,"d":"22.75"},{"v":23.0365045,"d":"23.04"},{"v":22.8815655,"d":"22.88"},{"v":120.827111666667,"d":"120.83"},{"v":139.441436666667,"d":"139.44"},{"v":111.731461666667,"d":"111.73"},{"v":160.677281666667,"d":"160.68"},0,1,1,1,0,4,{"v":0.295138782456738,"d":"0.295"},{"v":0.605675792895883,"d":"0.606"},{"v":0.0737986243764104,"d":"0.074"},{"v":13.2565045695497,"d":"13.26"},{"v":13.2639855526954,"d":"13.26"},"Unchanged",{"$nulls":3},"hsa-let-7a-5p"]
["hsa-let-7b-5p","hsa-let-7b-4395446","A",null,null,"Up",{"v":21.398109,"d":"21.40"},{"v":21.0599283333333,"d":"21.06"},{"v":21.1132036666667,"d":"21.11"},{"v":21.0652591666667,"d":"21.07"},{"v":409.15527,"d":"409.16"},{"v":493.172921666667,"d":"493.17"},{"v":451.764668333333,"d":"451.76"},{"v":654.088381666667,"d":"654.09"},0,2,1,2,0,4,{"v":0.0631404807145415,"d":"0.063"},{"v":0.414473706575804,"d":"0.414"},{"v":0.14212334559254,"d":"0.142"},{"v":13.5226107965982,"d":"13.52"},{"v":13.403907185477,"d":"13.40"},"Down",{"$nulls":3},"hsa-let-7b-5p"]
["hsa-miR-16-5p","hsa-miR-16-4373121","A",null,null,"Up",{"v":17.57629,"d":"17.58"},{"v":17.378647,"d":"17.38"},{"v":17.4141335,"d":"17.41"},{"v":17.463593,"d":"17.46"},{"v":4865.05729833333,"d":"4865.06"},{"v":5745.02178,"d":"5745.02"},{"v":5189.139705,"d":"5189.14"},{"v":6476.405895,"d":"6476.41"},0,2,0,1,0,4,{"v":0.19053591462729802,"d":"0.191"},{"v":0.5224308390607381,"d":"0.522"},{"v":0.0140758497380908,"d":"0.014"},{"v":14.7623079742106,"d":"14.76"},{"v":14.851180654965,"d":"14.85"},"Up",{"v":6558.204,"d":"6558.20"},{"v":6667.964,"d":"6667.96"},"Up","hsa-miR-16-5p"]
["hsa-miR-27a-5p","hsa-miR-27a*-4395556","B",null,"Down",null,{"v":25.4052343333333,"d":"25.41"},{"v":25.988443,"d":"25.99"},{"v":26.4095821666667,"d":"26.41"},{"v":26.2996468333333,"d":"26.30"},{"v":29.5552983333333,"d":"29.56"},{"v":21.1921466666667,"d":"21.19"},{"v":15.5330833333333,"d":"15.53"},{"v":22.5927666666667,"d":"22.59"},1,0,4,0,1,0,{"v":0.0309640419424232,"d":"0.031"},{"v":0.0330457408702814,"d":"0.033"},{"v":0.190966493408274,"d":"0.191"},{"v":6.36603363635611,"d":"6.37"},{"v":5.45124174760838,"d":"5.45"},"Down",{"$nulls":3},"hsa-miR-27a-5p"]
["hsa-miR-29a-3p","hsa-miR-29a-4395223","A",null,null,"Down",{"v":21.2745496666667,"d":"21.27"},{"v":21.8807846666667,"d":"21.88"},{"v":21.3587028333333,"d":"21.36"},{"v":22.0603221666667,"d":"22.06"},{"v":381.500875,"d":"381.50"},{"v":252.63121,"d":"252.63"},{"v":371.851551666667,"d":"371.85"},{"v":265.673631666667,"d":"265.67"},3,0,1,1,4,0,{"v":0.0725008801661578,"d":"0.073"},{"v":0.862255483414726,"d":"0.862"},{"v":0.0547793124539815,"d":"0.055"},{"v":12.7746839685167,"d":"12.77"},{"v":12.6119304691373,"d":"12.61"},"Down",{"v":967.1451,"d":"967.15"},{"v":578.1431,"d":"578.14"},"Down","hsa-miR-29a-3p"]
["hsa-miR-29b-1-5p","hsa-miR-29b-1*-4395276","B",null,null,"Down",{"v":30.7108465,"d":"30.71"},{"v":31.2566283333333,"d":"31.26"},{"v":30.9703871666667,"d":"30.97"},{"v":33.678408,"d":"33.68"},{"v":1.70749833333333,"d":"1.71"},{"v":0.7931216666666671,"d":"0.79"},{"v":0.8372033333333331,"d":"0.84"},{"v":0.49800833333333305,"d":"0.50"},2,1,2,0,4,0,{"v":0.32579575653117304,"d":"0.326"},{"v":0.24651766761316,"d":"0.247"},{"v":0.15086050738542,"d":"0.151"},{"v":4.63943357860144,"d":"4.64"},{"v":4.39477164678335,"d":"4.39"},"Down",{"$nulls":3},"hsa-miR-29b-1-5p"]
["hsa-miR-29c-3p","hsa-miR-29c-4395171","A",null,null,"Down",{"v":21.81638,"d":"21.82"},{"v":22.3418483333333,"d":"22.34"},{"v":21.9270073333333,"d":"21.93"},{"v":22.5744956666667,"d":"22.57"},{"v":259.652583333333,"d":"259.65"},{"v":190.757685,"d":"190.76"},{"v":240.274316666667,"d":"240.27"},{"v":186.994818333333,"d":"186.99"},3,0,1,1,4,0,{"v":0.00650051584046601,"d":"0.007"},{"v":0.585281162026804,"d":"0.585"},{"v":0.016530211743288798,"d":"0.017"},{"v":8.13901648334403,"d":"8.14"},{"v":7.59939543762592,"d":"7.60"},"Down",{"v":427.6831,"d":"427.68"},{"v":259.1861,"d":"259.19"},"Down","hsa-miR-29c-3p"]
["hsa-miR-95","hsa-miR-95-4373011","A",null,null,"Down",{"v":27.04565,"d":"27.05"},{"v":27.5000906666667,"d":"27.50"},{"v":27.0938463333333,"d":"27.09"},{"v":27.9086951666667,"d":"27.91"},{"v":6.81213666666667,"d":"6.81"},{"v":5.28785833333333,"d":"5.29"},{"v":7.02212,"d":"7.02"},{"v":4.596495,"d":"4.60"},2,0,1,1,4,0,{"v":0.052370097209234696,"d":"0.052"},{"v":0.8999996375947761,"d":"0.900"},{"v":0.00980603034544255,"d":"0.010"},{"v":4.17447064815136,"d":"4.17"},{"v":4.11921319866939,"d":"4.12"},"Down",{"$nulls":3},"hsa-miR-95"]
["hsa-miR-149-5p","hsa-miR-149-4395366","A",null,"Down","Down",{"v":29.3149218333333,"d":"29.31"},{"v":33.9606781666667,"d":"33.96"},{"v":32.8563528333333,"d":"32.86"},{"v":36.9471778333333,"d":"36.95"},{"v":1.935935,"d":"1.94"},{"v":0.547611666666667,"d":"0.55"},{"v":0.547375,"d":"0.55"},{"v":0.0433066666666667,"d":"0.04"},3,0,5,0,5,0,{"v":0.0505023971245667,"d":"0.051"},{"v":0.0038599538974012503,"d":"0.004"},{"v":0.0117928363675185,"d":"0.012"},{"v":4.65987670700387,"d":"4.66"},{"v":4.48072227510248,"d":"4.48"},"Down",{"v":0.09643417,"d":"0.10"},{"v":0.0817625,"d":"0.08"},"Down","hsa-miR-149-5p"]
["hsa-miR-181c-3p","hsa-miR-181c*-4395444","B",null,null,"Down",{"v":29.8264828333333,"d":"29.83"},{"v":29.9190091666667,"d":"29.92"},{"v":31.2165223333333,"d":"31.22"},{"v":32.3030851666667,"d":"32.30"},{"v":3.3800166666666698,"d":"3.38"},{"v":2.82723666666667,"d":"2.83"},{"v":3.4926133333333302,"d":"3.49"},{"v":1.7861,"d":"1.79"},2,1,1,1,4,0,{"v":0.67631771094444,"d":"0.676"},{"v":0.922925294894504,"d":"0.923"},{"v":0.11595622961073901,"d":"0.116"},{"v":7.15525175884779,"d":"7.16"},{"v":7.14559529257146,"d":"7.15"},"Unchanged",{"$nulls":3},"hsa-miR-181c-3p"]
["hsa-miR-193a-3p","hsa-miR-193a-3p-4395361","A",null,"Down",null,{"v":32.7676581666667,"d":"32.77"},{"v":34.5849693333333,"d":"34.58"},{"v":36.1248788333333,"d":"36.12"},{"v":34.4480308333333,"d":"34.45"},{"v":0.23644,"d":"0.24"},{"v":0.207915,"d":"0.21"},{"v":0.0868616666666667,"d":"0.09"},{"v":0.27330666666666703,"d":"0.27"},2,1,4,1,2,0,{"v":0.8165752878160981,"d":"0.817"},{"v":0.25437386385551,"d":"0.254"},{"v":0.7709612521111231,"d":"0.771"},{"v":4.93794852352791,"d":"4.94"},{"v":4.60181485170433,"d":"4.60"},"Down",{"$nulls":3},"hsa-miR-193a-3p"]
["hsa-miR-193a-5p","hsa-miR-193a-5p-4395392","A",null,"Down",null,{"v":27.4537928333333,"d":"27.45"},{"v":27.8889681666667,"d":"27.89"},{"v":28.1327866666667,"d":"28.13"},{"v":27.7924243333333,"d":"27.79"},{"v":5.40562,"d":"5.41"},{"v":3.991855,"d":"3.99"},{"v":3.34383333333333,"d":"3.34"},{"v":5.19229666666667,"d":"5.19"},3,0,4,0,1,0,{"v":0.0905651874336021,"d":"0.091"},{"v":0.0236909095983481,"d":"0.024"},{"v":0.7245539169995421,"d":"0.725"},{"v":6.93924150018715,"d":"6.94"},{"v":6.42275923722145,"d":"6.42"},"Down",{"$nulls":3},"hsa-miR-193a-5p"]
["hsa-miR-342-5p","hsa-miR-342-5p-4395258","A",null,null,"Up",{"v":25.6036516666667,"d":"25.60"},{"v":26.0251265,"d":"26.03"},{"v":25.2916218333333,"d":"25.29"},{"v":25.0902395,"d":"25.09"},{"v":20.6412366666667,"d":"20.64"},{"v":14.901208333333301,"d":"14.90"},{"v":26.5727866666667,"d":"26.57"},{"v":34.581945,"d":"34.58"},2,0,1,2,0,4,{"v":0.17260288915434702,"d":"0.173"},{"v":0.25684741844507,"d":"0.257"},{"v":0.10397579259142,"d":"0.104"},{"v":10.2744573203541,"d":"10.27"},{"v":10.2954559823814,"d":"10.30"},"Unchanged",{"$nulls":3},"hsa-miR-342-5p"]
["hsa-miR-346","hsa-miR-346-4373038","A",null,null,"Up",{"v":28.0922815,"d":"28.09"},{"v":27.6299671666667,"d":"27.63"},{"v":27.5687391666667,"d":"27.57"},{"v":27.515057,"d":"27.52"},{"v":4.6169066666666705,"d":"4.62"},{"v":6.69081,"d":"6.69"},{"v":9.242115,"d":"9.24"},{"v":8.76226333333333,"d":"8.76"},1,3,1,3,0,4,{"v":0.31317509753710504,"d":"0.313"},{"v":0.26880328573399503,"d":"0.269"},{"v":0.0258567080722601,"d":"0.026"},{"v":5.31621336719297,"d":"5.32"},{"v":5.23282708046196,"d":"5.23"},"Down",{"$nulls":3},"hsa-miR-346"]
["hsa-miR-423-5p","hsa-miR-423-5p-4395451","A",null,null,"Down",{"v":27.0171073333333,"d":"27.02"},{"v":28.679142,"d":"28.68"},{"v":26.542401,"d":"26.54"},{"v":29.7635481666667,"d":"29.76"},{"v":8.42367833333333,"d":"8.42"},{"v":8.56782833333333,"d":"8.57"},{"v":11.3343416666667,"d":"11.33"},{"v":5.02916833333333,"d":"5.03"},1,1,0,2,4,0,{"v":0.94163753779228,"d":"0.942"},{"v":0.22188404344669602,"d":"0.222"},{"v":0.0091285901928911,"d":"0.009"},{"v":10.8693321271902,"d":"10.87"},{"v":10.676470729374,"d":"10.68"},"Down",{"$nulls":3},"hsa-miR-423-5p"]
["hsa-miR-518b","hsa-miR-518b-4373246","A",null,null,"Up",{"v":32.2670993333333,"d":"32.27"},{"v":31.8235638333333,"d":"31.82"},{"v":31.6360601666667,"d":"31.64"},{"v":30.196098,"d":"30.20"},{"v":0.5887983333333331,"d":"0.59"},{"v":0.9023700000000001,"d":"0.90"},{"v":0.9805966666666671,"d":"0.98"},{"v":1.4255900000000001,"d":"1.43"},1,3,0,2,0,4,{"v":0.25438527877836997,"d":"0.254"},{"v":0.47556452645108205,"d":"0.476"},{"v":0.0268769815655342,"d":"0.027"},{"v":4.16825758205931,"d":"4.17"},{"v":4.16281912780758,"d":"4.16"},"Unchanged",{"$nulls":3},"hsa-miR-518b"]
["hsa-miR-532-5p","hsa-miR-532-5p-4380928","A",null,"Down",null,{"v":23.2719431666667,"d":"23.27"},{"v":23.8329501666667,"d":"23.83"},{"v":23.6592133333333,"d":"23.66"},{"v":23.8752616666667,"d":"23.88"},{"v":93.6557866666667,"d":"93.66"},{"v":71.0328133333333,"d":"71.03"},{"v":69.7959233333333,"d":"69.80"},{"v":74.9240166666667,"d":"74.92"},1,0,4,0,2,0,{"v":0.20751809166680601,"d":"0.208"},{"v":0.0006965442300603921,"d":"0.001"},{"v":0.019816183625666003,"d":"0.020"},{"v":9.69184106004363,"d":"9.69"},{"v":9.41721361302014,"d":"9.42"},"Down",{"v":36.25224,"d":"36.25"},{"v":30.45831,"d":"30.46"},"Down","hsa-miR-532-5p"]
["hsa-miR-708-5p","hsa-miR-708-4395452","A",null,"Down","Down",{"v":29.5776858333333,"d":"29.58"},{"v":30.2427321666667,"d":"30.24"},{"v":30.8376071666667,"d":"30.84"},{"v":30.8298436666667,"d":"30.83"},{"v":2.07302666666667,"d":"2.07"},{"v":1.18080666666667,"d":"1.18"},{"v":0.8590800000000001,"d":"0.86"},{"v":0.796485,"d":"0.80"},2,0,4,0,4,0,{"v":0.100376737081539,"d":"0.100"},{"v":0.0598985388557757,"d":"0.060"},{"v":0.0887484884965033,"d":"0.089"},{"v":4.72580879891038,"d":"4.73"},{"v":4.62710493719454,"d":"4.63"},"Down",{"$nulls":3},"hsa-miR-708-5p"]
["hsa-miR-760","hsa-miR-760-4395439","B","Up",null,null,{"v":28.7865841666667,"d":"28.79"},{"v":26.6572545,"d":"26.66"},{"v":26.8373155,"d":"26.84"},{"v":27.0740186666667,"d":"27.07"},{"v":10.4338916666667,"d":"10.43"},{"v":22.9743783333333,"d":"22.97"},{"v":17.4315633333333,"d":"17.43"},{"v":15.16979,"d":"15.17"},1,4,1,3,0,2,{"v":0.239273681203776,"d":"0.239"},{"v":0.34805054864335605,"d":"0.348"},{"v":0.0412043698821581,"d":"0.041"},{"v":6.08061949381899,"d":"6.08"},{"v":5.58079309138718,"d":"5.58"},"Down",{"$nulls":3},"hsa-miR-760"]
["hsa-miR-874","hsa-miR-874-4395379","A","Down",null,null,{"v":26.8162458333333,"d":"26.82"},{"v":31.1503863333333,"d":"31.15"},{"v":28.3668788333333,"d":"28.37"},{"v":31.9011223333333,"d":"31.90"},{"v":10.9961616666667,"d":"11.00"},{"v":4.70969166666667,"d":"4.71"},{"v":10.5531933333333,"d":"10.55"},{"v":8.006025,"d":"8.01"},4,0,1,2,3,0,{"v":0.0304272820636981,"d":"0.030"},{"v":0.861992878855632,"d":"0.862"},{"v":0.280595864656691,"d":"0.281"},{"v":7.82909772745436,"d":"7.83"},{"v":7.34052926465826,"d":"7.34"},"Down",{"$nulls":3},"hsa-miR-874"]
[]
["Legends","The TaqMan microRNA assay",null,"The filtering result is summarized here according to the following scheme",{"$nulls":10},"The number of patients that showed a strong up- or down-regulation (|MAID|>1.0) at this time point compared to baseline",{"$nulls":11},"The results of the validation experiment using TaqMan single-tube assays"]
[{"$nulls":3},"Up","The miRNA was filtered as up-regulated at this time point in comparison to baseline",{"$nulls":10},"The miRNA was filtered because at least 4 patients showed a strong change in expression",{"$nulls":10},"Given are the normalized expression values averaged over the independent cohort of patients (n=12)"]
[{"$nulls":4},"The average expression of this miRNA was just higher at this time point compared to the mean pre-treatment level",{"$nulls":21},"The difference of the expression levels indicates up- or down-regulation"]
[{"$nulls":4},"The average expression of this miRNA was just lower at this time point compared to the mean pre-treatment level",{"$nulls":15},"The p-values of the paired t-tests comparing the expression during therapy versus baseline"]
[{"$nulls":3},"Down","The miRNA was filtered as down-regulated at this time point in comparison to baseline",{"$nulls":16},"The miRNA was differentially expressed with p-value<0.05"]
[{"$nulls":3},"t0 = baseline"]
[{"$nulls":3},"t1 = day 2",null,null,"The average expression over all 6 patients per time point and miRNA (TaqMan miRNA Cards, non-normalized data, i.e. raw Ct values)",{"$nulls":16},"The results of the validation experiment using Affymetrix miRNA arrays"]
[{"$nulls":3},"t2 = day 4",{"$nulls":19},"Given are the normalized expression values averaged over the patients (Pat1-3)"]
[{"$nulls":3},"t3 = month 1",{"$nulls":6},"The average expression over all 6 patients per time point and miRNA (TaqMan miRNA Cards, normalized data)",{"$nulls":12},"The difference of the expression levels after one month of IFN-beta therapy compared to baseline indicates up- or down-regulation"]
[{"$nulls":23},"Unchanged","The label \"unchanged\" was given, if the difference in expression was <0.05"]