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["Supplemental Table S1. Identification of differentially expressed proteins of A. catenella CI01 at different toxin biosynthesis stages."]
["Spot ID a.","NCBI b","Protein name","Theoretical  pI","Theoretical  MW","No. of matched peptides","Sequence\nCoverage\n(%)\n","Protein score","Protein score C.I.%","Function","T28 vs T24",null,"T34 vs T24"]
[{"$nulls":10},"Fold change c","P-Value","Fold change","P-Value"]
["Protein modification"]
[1,26991410,"chaperone protein DnaK",4.83,68.87,10,38,88,98.32,"protein folding; response to stress",0.46,0.031,{"v":1.2,"d":"1.20"},0.102]
[3,215400773,"Hsp70-type chaperone",5.04,68.81,8,45,137,100,"Heat shock protein 70 family; protein folding",0.76,0.839,2.67,0.006]
[7,148549568,"Chaperonin GroEL",4.97,56.75,13,51,334,100,"Protein and ATP binding",0.32,0.021,1.34,0.518]
[12,148549568,null,4.97,56.75,23,89,730,100,null,{"v":2.2,"d":"2.20"},0.002,{"v":1.5,"d":"1.50"},0.106]
["Metabolism"]
[8,170723674,"serine hydroxymethyltransferase",5.85,45.18,6,80,101,99.91,"L-serine,glycine,one-carbon metabolic process",0.44,0.015,0.83,0.572]
[42,70732651,null,5.74,45.15,5,46,93,99.49,null,0.35,0.002,0.62,0.023]
[15,35210480,"glyceraldehyde-3-phosphate dehydrogenase",4.81,26.21,1,63,248,95.24,"Glucose metabolic process;oxidation reduction",{"v":1.2,"d":"1.20"},0.621,2.06,0.003]
[16,35210480,null,4.81,26.21,1,77,248,100,null,2.21,0.093,3.67,0.003]
[17,35210480,null,4.81,26.21,1,31,101,100,null,{"v":0.3,"d":"0.30"},0.241,2.45,0.018]
[83,35210480,null,4.81,26.21,1,89,248,100,null,0.49,0.015,0.25,0.002]
[19,58613475,"phosphoglycerate kinase",6.16,27.32,1,48,271,100,"Glycolysis",2.19,0.074,3.47,0.003]
[37,58613.455,"Chloroplast ferredoxin-NADP+ reductase",4.78,28.67,2,90,389,100,"ferredoxin-NADP reductase type 1 family;Oxidation reduction",0.13,0.007,1.19,0.641]
[40,170723385,"ornithine carbamoyltransferase",5.92,{"v":38.1,"d":"38.10"},15,68,296,100,"Cellular amino acid metabolic process",0.45,0.088,1.61,0.003]
[31,46909371,"Methionine (S-) adenosyltransferase",5.81,34.39,4,29,145,100,"Transferase; one-carbon metabolic",1.26,{"v":0.45,"d":"0.450"},{"v":0.4,"d":"0.40"},0.043]
[32,158524698,null,5.59,{"v":35.3,"d":"35.30"},3,73,149,100,null,1.89,0.173,0.47,0.033]
[33,71370920,null,6.82,35.08,3,77,202,100,null,1.15,0.767,{"v":0.4,"d":"0.40"},0.034]
[34,225685869,null,5.54,45.52,3,90,121,100,null,0.92,0.942,0.46,0.042]
[36,225685865,null,5.73,51.08,4,93,92,99.248,null,{"v":2.5,"d":"2.50"},0.007,0.18,0.091]
[41,104782658,"succinyl-CoA synthetase subunit beta",5.83,41.47,3,39,92,99.27,"Tricarboxylic acid cycle",0.32,0.024,1.55,0.058]
[45,134037072,"plastid oxygen-evolving enhancer 1–2 precursor",5.37,27.84,1,95,333,97.61,"Photosynthesis; photosystemⅡ stabilization",0.38,0.198,1.24,0.801]
[47,118577178,"Chorismatemutase/prephenatedehydratas",{"v":6.6,"d":"6.60"},25.75,7,70,85,96.79,"L-phenylalanine biosynthetic process",0.48,0.135,3.11,"<0.001"]
[49,149071995,"photosystem I assembly protein ycf1",9.79,26.39,2,85,80,100,"photosynthesis",{"v":0.1,"d":"0.10"},0.205,3.63,0.002]
[52,170723490,"nucleoside-diphosphate kinase",5.23,{"v":15,"d":"15.00"},7,85,298,100,"CTP,GTP,UTP biosynthetic process",0.55,0.845,2.52,0.125]
[54,56693619,"protein kinase C conserved region 2",{"v":8.7,"d":"8.70"},23.29,2,64,64.3,99.98,"Transferase;kinase activity",0.92,0.995,2.12,0.073]
[55,26987276,"inorganic pyrophosphatase",4.77,19.18,2,82,87,97.73,"Phosphate metabolic process",{"v":1,"d":"1.00"},{"v":1,"d":"1.000"},11.55,0.003]
[56,3355306,"light-harvesting polyprotein precursor",5.26,22.37,2,98,1671,100,"Photosynthesis,light harvesting",0.46,0.008,0.54,0.018]
[67,219114000,"fructose-bisphosphate aldolase",9.71,27.23,1,90,185,100,"Glycolysis",2.18,"<0.001",1.06,0.947]
[69,71000213,"enolase 2",5.07,40.57,7,20,205,100,"glycolysis",2.88,0.006,{"v":0.8,"d":"0.80"},0.923]
[78,148546281,"arginine deiminase",5.66,46.73,18,71,660,100,"arginine catabolic process; Inhibits Cell Proliferation; Arresting Cell Cycle and Inducing Apoptosis",{"v":3.3,"d":"3.30"},"<0.001",{"v":0.2,"d":"0.20"},0.008]
[60,75284311,"ribulose 1,5-bisphosphate carboxylase, chloroplastic;",7.01,28.88,2,95,476,99.99,"Oxidation reduction; photorespiration; reductive pentose-phosphate cycle",0.46,0.072,0.87,0.861]
[68,75284311,null,7.01,28.88,2,94,476,99.99,null,2.14,0.005,1.02,{"v":1,"d":"1.000"}]
[75,37730371,null,6.26,60.21,6,94,95,99.64,null,2.52,0.008,0.81,0.903]
[71,75284311,null,7.01,28.89,1,97,476,99.43,null,8.11,0.001,1.08,{"v":1,"d":"1.000"}]
[70,37731771,"ribulose 1,5-bisphosphate carboxylase oxygenase form II (small subunit)",6.09,34.03,5,95,144,100,"Oxidation reduction; photorespiration; reductive pentose-phosphate cycle",0.37,0.298,2.21,0.037]
[72,33317821,"ribulose 1,5-bisphosphate carboxylase oxygenase large subunit",5.66,50.47,5,95,89,98.57,"Oxidation reduction; photorespiration; reductive pentose-phosphate cycle",3.05,0.022,1.32,0.901]
[73,33317821,null,5.66,50.47,4,93,135,100,null,2.96,0.048,1.13,0.996]
[74,33317821,null,5.66,50.47,4,95,135,100,null,3.36,{"v":0.11,"d":"0.110"},1.07,{"v":1,"d":"1.000"}]
[76,211939908,"adenosylhomocysteinase (AdoHcy)",5.74,27.97,8,79,150,100,"one-carbon metabolic process; an enzyme that converts SAH to homocysteine and adenosine",{"v":2.2,"d":"2.20"},0.003,0.49,0.117]
[79,211939908,null,5.74,27.97,7,83,116,99.99,null,3.32,0.003,0.88,0.985]
[77,211939908,"S-adenosylhomocysteinase (SAH)",5.74,27.97,9,89,120,99.99,"one-carbon metabolic process; an intermediate in the synthesis of cysteine and formed by the demethylation of SAM",2.89,0.001,0.86,0.905]
[82,257480821,"plastid protein NAP50",5.72,51.89,6,91,111,100,"Nitrogen-associated protein 50.",0.99,{"v":1,"d":"1.000"},{"v":2.2,"d":"2.20"},0.011]
[88,257480821,null,5.72,51.89,7,75,138,100,null,{"v":1.1,"d":"1.10"},0.991,2.26,0.051]
[89,257480821,null,5.72,51.89,7,75,90,98.91,null,2.02,0.073,1.33,0.735]
[93,27450755,"chlorophyll A–C binding protein",5.26,22.37,2,69,183,100,"photosynthesis",0.39,0.102,1.78,0.041]
[94,115901552,"similar to sulfotransferase (SULT)",{"v":4.7,"d":"4.70"},35.22,1,88,122,96.24,"sulfotransferase activity",0.44,0.043,1.24,0.459]
["Cell cycle regulation"]
[9,163750818,"Cell division protein FtsH",4.89,{"v":71.9,"d":"71.90"},10,64,135,100,"Cell division; proteolysis",3.43,0.058,0.79,{"v":0.99,"d":"0.990"}]
[38,169831563,"formamidopyrimidine-DNA glycosylase",9.73,31.35,7,83,77,95.44,"DNA damage ;DNA repair ;base-excision repair",0.37,0.628,4.42,0.003]
[39,169831563,null,{"v":8.7,"d":"8.70"},34.35,7,57,77,95.44,null,0.48,0.963,5.22,0.039]
[62,134037078,"DNA damage checkpoint protein rad24",{"v":5,"d":"5.00"},26.53,8,33,158,100,"Protein domain specific binding",{"v":0.3,"d":"0.30"},0.005,0.97,0.993]
[64,134037086,"DNA damage checkpoint protein rad17",4.96,27.33,9,17,168,100,"14-3-3 family; Protein domain specific binding",0.38,0.136,1.63,{"v":0.13,"d":"0.130"}]
["Oxidative stress response"]
[10,112253644,"heat shock protein 70",{"v":5.1,"d":"5.10"},70.14,21,91,492,100,"Response to stress",0.82,0.741,2.24,0.002]
[11,112253644,null,4.93,28.48,1,35,444,97.85,null,2.01,0.002,0.53,0.075]
[14,294873483,null,7.22,34.64,1,87,55,99.9,null,0.79,0.984,3.73,0.018]
[18,294873483,null,7.22,34.64,2,33,111,100,null,{"v":2.1,"d":"2.100"},0.365,{"v":3.43,"d":"3.430"},0.031]
[53,26987945,"DNA-binding stress protein",{"v":5.2,"d":"5.20"},17.85,8,19,172,100,null,{"v":0.34,"d":"0.340"},0.626,{"v":4.88,"d":"4.880"},0.002]
[59,118490698,"cytochrome c oxidase subunit, putative",5.63,22.69,2,74,198,99.91,"Cellcular iron ion homeostasis; oxidation reduction;response to stress",{"v":0.19,"d":"0.190"},0.004,{"v":0.37,"d":"0.370"},0.014]
[84,26991362,"ketol-acid reductoisomerase",5.48,36.58,3,27,103,99.95,"Amino-acid biosynthesis; oxidoreductase\n",{"v":0.39,"d":"0.390"},0.302,{"v":1.41,"d":"1.410"},0.583]
[95,26990544,"alcohol dehydrogenase",5.61,35.89,6,68,110,99.99,"Oxidation reduction;zinc ion binding",{"v":0.45,"d":"0.450"},0.871,{"v":7.63,"d":"7.630"},0.001]
[96,219848105,"RNA binding S1 domain protein",5.42,{"v":27,"d":"27.00"},1,65,54,100,"similar to cold shock protein, Response to stress",0.88,0.928,2.24,0.004]
[20,166030338,"luciferin-binding protein",5.59,75.06,26,95,299,100,null,0.46,0.393,{"v":2.3,"d":"2.30"},0.026]
[22,166030338,null,5.59,75.06,28,95,519,100,"Specific substrate-binding protein, clock-controlled repressor",2.89,0.003,1.25,0.832]
[23,166030338,null,5.59,75.06,21,90,108,99.98,null,0.46,0.056,0.67,0.578]
[24,166030338,null,5.51,29.08,1,55,460,95.04,null,1.34,0.919,6.22,"<0.001"]
[25,166030338,null,5.59,75.06,12,92,107,99.98,null,1.02,{"v":1,"d":"1.000"},2.03,0.013]
[26,166030338,null,5.59,75.06,14,97,165,100,null,1.36,0.326,{"v":2,"d":"2.00"},0.009]
[27,166030338,null,5.59,75.06,13,97,96,99.75,null,0.62,0.097,{"v":0.2,"d":"0.20"},0.004]
[28,166030338,null,5.59,75.06,16,99,330,100,null,0.39,0.008,0.82,0.453]
[29,166030338,null,6.03,28.81,1,95,640,99.14,null,{"v":0.4,"d":"0.40"},{"v":0.02,"d":"0.020"},0.22,0.006]
["Translation"]
[6,301500981,"elongation factor Tu",4.73,26.88,2,99,316,100,"Protein biosynthesis; translation elongation factor activity",0.45,0.015,0.79,0.363]
[91,30468209,null,9.81,27.69,2,97,141,100,null,2.89,0.013,2.34,0.058]
[92,30468209,null,9.81,27.69,2,95,141,100,null,0.69,0.084,0.49,0.011]
[61,26988588,"elongation factor P",4.73,21.35,5,99,140,100,"Elongation factor P family; Protein biosynthesis",0.49,0.077,{"v":1.1,"d":"1.10"},0.921]
[63,167032445,null,4.77,21.38,4,95,127,100,null,0.49,0.027,0.89,0.809]
[50,167033775,"Hcp1 family type VI secretion system effector",5.64,18.59,6,29,340,100,"as an extracellular T6SS translocon",{"v":0.1,"d":"0.10"},0.379,4.47,0.002]
["Signal transduction"]
[5,26991228,"hypothetical protein PP_4544",4.87,45.27,14,99,437,100,"Signal peptide; chain",0.69,{"v":0.22,"d":"0.220"},2.92,"<0.001"]
["Transport"]
[2,41055863,"nuclear pore complex protein Nup155",5.77,26.56,1,99,196,95.2,"Nucleocytoplasmic transport",2.07,{"v":0.02,"d":"0.020"},2.32,0.007]
[65,41055863,null,5.77,26.56,1,97,196,95.58,null,{"v":2.1,"d":"2.10"},0.083,0.97,{"v":1,"d":"1.000"}]
[97,41055863,null,5.77,26.56,3,94,196,97.13,null,0.44,0.014,{"v":1.2,"d":"1.20"},0.405]
[4,26992088,"ATP synthase F1, beta subunit",4.88,49.39,12,89,445,100,"ATP synthesis coupled proton transport",0.67,0.933,2.59,{"v":0.06,"d":"0.060"}]
[48,222053555,null,4.89,{"v":51,"d":"51.00"},7,95,355,100,null,0.89,0.963,2.01,0.022]
[46,156350099,"hypothetical protein NEMVEDRAFT_v1g142315",5.77,26.56,1,85,310,95.57,"Nucleocytoplasmic transport",0.39,0.007,2.02,"<0.001"]
[81,156350099,null,5.77,26.56,1,95,310,95.39,null,0.82,0.984,2.04,0.195]
[58,294929773,"UDP-N-acetylglucosamine–dolichyl-phosphate",8.17,28.52,2,43,416,100,"transferase",1.12,{"v":0.97,"d":"0.970"},2.37,0.012]
[66,26988814,"OmpF family protein",4.72,37.22,2,93,700,100,"Membrane; porin activity",0.49,0.075,1.32,0.294]
[87,26987153,"polyamine ABC transporter, periplasmic polyamine-binding protein",5.62,37.89,4,65,118,99.99,"Transporter activity",1.15,0.926,2.13,0.005]
["Protein biosynthesis"]
[85,134037068,"Actin",5.26,41.95,8,57,187,100,"Protein and  ATP binding",{"v":0.9,"d":"0.90"},0.998,3.79,0.013]
[98,86355884,"formyltetrahydrofolate deformylase",6.26,32.96,4,41,156,100,"de novo' IMP biosynthetic process",0.82,0.929,2.44,0.014]
["Uncharacterized proteins"]
[13,294955276,"hypothetical protein Pmar_PMAR010017",11.15,27.93,1,99,485,95.07,"uncharacterized",0.78,0.336,{"v":2.1,"d":"2.10"},"<0.001"]
[35,294950255,"hypothetical protein Pmar_PMAR005244",9.18,{"v":25.3,"d":"25.30"},1,66,416,98.9,null,{"v":0.5,"d":"0.50"},0.002,0.05,"<0.001"]
[57,294950255,null,6.03,27.81,1,47,416,97.84,null,0.64,0.181,0.48,0.053]
[90,294950255,null,6.03,27.81,1,68,416,97.71,null,1.57,0.162,0.48,0.209]
["Unknown proteins"]
[21,null,null,8.89,20.88,2,null,165,100,null,0.92,0.977,2.05,{"v":0.01,"d":"0.010"}]
[44,null,null,10.25,24.23,1,null,38,96.9,null,0.44,0.098,1.91,0.014]
["Unidentified proteins"]
[30,{"$nulls":9},0.18,"<0.001",0.36,0.001]
[43,{"$nulls":9},0.48,0.104,0.82,0.753]
[51,{"$nulls":9},1.34,{"v":0.73,"d":"0.730"},2.63,0.011]
[80,{"$nulls":9},{"v":0.5,"d":"0.50"},0.022,0.72,{"v":0.18,"d":"0.180"}]
[86,{"$nulls":9},0.34,0.059,0.72,0.525]
[99,{"$nulls":9},0.46,0.145,{"v":1.1,"d":"1.10"},0.959]
[100,{"$nulls":9},0.35,0.009,0.78,0.368]
[101,{"$nulls":9},0.32,0.094,1.35,0.478]
[102,{"$nulls":9},0.36,0.862,7.44,0.001]
["a  Spot ID represents the protein spot number on the 2-D gels."]
["b  Accession numbers according to the NCBI database."]
["c  Spot abundance is expressed as the average optical density of up-regulated or down-regulated proteins at T24, T28 and T34. "]

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